A New Subtype of Pre-B Acute Lymphoblastic Leukemia With t(5; 12)(q31q33; p12), Molecularly and Cytogenetically Distinct From t(5; 12) in Chronic Myelomonocytic Leukemia
| Autor: | Anna Aventin, D Falzetti, Arnold Criel, Júlia Inglés-Esteve, Jean-Jacques Cassiman, Iwona Wlodarska, Peter Marynen, Herman Van den Berghe, Cristina Mecucci |
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| Rok vydání: | 1997 |
| Předmět: |
Immunology
Chronic myelomonocytic leukemia Chromosomal translocation Pre-B Acute Lymphoblastic Leukemia Biology Biochemistry Translocation Genetic Immunophenotyping Precursor B-Cell Lymphoblastic Leukemia-Lymphoma hemic and lymphatic diseases Acute lymphocytic leukemia medicine Humans In Situ Hybridization Fluorescence Genetics Chromosomes Human Pair 12 medicine.diagnostic_test Leukemia Myelomonocytic Chronic Cell Biology Hematology medicine.disease Molecular biology Leukemia ETV6 Chromosomes Human Pair 2 Acute Disease Fluorescence in situ hybridization |
| Zdroj: | Blood. 89:1716-1722 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v89.5.1716 |
| Popis: | Translocation t(5; 12)(q33; p13), resulting in an ETV6/PDGFRB gene fusion, is a recurrent chromosomal abnormality associated with chronic myelomonocytic leukemia (CMML). An analogous translocation was also found in four cell lines with features of pre-B acute lymphoblastic leukemia (ALL). Using fluorescence in situ hybridization (FISH) we show here that in three of these cell lines identical complex rearrangements occurred. However, the regions involved on 5q and 12p are different from the breakpoints in CMML, and the translocation is accompanied by seemingly identical cryptic deletions of both 5q and 12p chromosome sequences in all analyzed pre-B ALL cell lines. The similar cytogenetic, FISH, and immunophenotyping findings in the three cell lines suggest that the t(5; 12)(q31q33; p12) defines a new entity of pre-B ALL. |
| Databáze: | OpenAIRE |
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