Difference of immune cell infiltration between stable and unstable carotid artery atherosclerosis
| Autor: | Li-Cheng Shi, Jian-Hua Gu, Dan-Dan Zhang, Wenjun Wang, Xuan-Feng Zhu, Jian-Nan Liu, Jia Gao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Carotid Artery Diseases
Pathology medicine.medical_specialty Cell type Microarray Carotid arteries Plasma Cells Cell Myocardial Infarction CD8-Positive T-Lymphocytes Brain Ischemia Memory T Cells Immune system Memory B Cells Follicular phase carotid artery atherosclerosis medicine Humans M2 macrophages Cytotoxic T cell Myocardial infarction immune infiltration Chemistry Macrophages CIBERSORT unstable atherosclerosis Original Articles Cell Biology Atherosclerosis medicine.disease Plaque Atherosclerotic Stroke Carotid Arteries medicine.anatomical_structure Molecular Medicine Original Article |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/jcmm.17018 |
| Popis: | Atherosclerotic plaque instability contributes to ischaemic stroke and myocardial infarction. This study is to compare the abundance and difference of immune cell subtypes within unstable atherosclerotic tissues. CIBERSORT was used to speculate the proportions of 22 immune cell types based on a microarray of atherosclerotic carotid artery samples. R software was utilized to illustrate the bar plot, heat map and vioplot. The immune cell landscape in atherosclerosis was diverse, dominated by M2 macrophages, M0 macrophages, resting CD4 memory T cells and CD8 T cells. There was a significant difference in resting CD4 memory T cells (p = 0.032), T cells follicular helper (p = 0.033), M0 (p = 0.047) and M2 macrophages (p = 0.012) between stable and unstable atherosclerotic plaques. Compared with stable atherosclerotic plaques, unstable atherosclerotic plaques had a higher percentage of M2 macrophages. Moreover, correlation analysis indicated that the percentage of naïve CD4 T cells was strongly correlated with that of gamma delta T cells (r = 0.93, p |
| Databáze: | OpenAIRE |
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