Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology
| Autor: | Mühleder, Severin, Fernández-Chacón, Macarena, Garcia-Gonzalez, Irene, Benedito, Rui |
|---|---|
| Přispěvatelé: | FWF Austrian Science Fund, Fundación La Caixa, European Research Council, Centro Nacional de Investigaciones Cardiovasculares Carlos III (España), Ministerio de Economía, Industria y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Fundación ProCNIC |
| Rok vydání: | 2020 |
| Předmět: |
Senescence
Aging Cell cycle checkpoint Vascular differentiation Angiogenesis Endothelial cells medicine.medical_treatment Neovascularization Physiologic Review Disease Biology Cell-cycle arrest Regenerative medicine 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cell Movement Neoplasms medicine Humans Molecular Biology Cell Proliferation 030304 developmental biology Feedback Physiological Pharmacology 0303 health sciences Neovascularization Pathologic Cell growth Growth factor Endothelial Cells Cell Biology Cell biology Cardiovascular Diseases 030220 oncology & carcinogenesis Malformations Molecular Medicine Signal transduction Sprouting Signal Transduction |
| Zdroj: | Cellular and Molecular Life Sciences Repisalud Instituto de Salud Carlos III (ISCIII) |
| ISSN: | 1420-9071 1420-682X |
| DOI: | 10.1007/s00018-020-03664-y |
| Popis: | Therapeutic modulation of vascular cell proliferation and migration is essential for the effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The general view is that an increase in vascular growth factor levels or mitogenic stimulation is beneficial for angiogenesis, since it leads to an increase in both endothelial proliferation and sprouting. However, several recent studies showed that an increase in mitogenic stimuli can also lead to the arrest of angiogenesis. This is due to the existence of intrinsic signaling feedback loops and cell cycle checkpoints that work in synchrony to maintain a balance between endothelial proliferation and sprouting. This balance is tightly and effectively regulated during tissue growth and is often deregulated or impaired in disease. Most therapeutic strategies used so far to promote vascular growth simply increase mitogenic stimuli, without taking into account its deleterious effects on this balance and on vascular cells. Here, we review the main findings on the mechanisms controlling physiological vascular sprouting, proliferation, and senescence and how those mechanisms are often deregulated in acquired or congenital cardiovascular disease leading to a diverse range of pathologies. We also discuss alternative approaches to increase the effectiveness of pro-angiogenic therapies in cardiovascular regenerative medicine. Severin Mühleder was funded by the Austrian Science Fund (FWF) project J4358. Macarena Fernández-Chacón and Irene Garcia-Gonzalez were supported by PhD fellowships from Fundación La Caixa (CX_E-2015-01 and CX-SO-16-1, respectively). Rui Benedito was funded by the European Research Council (ERC-2014-StG—638028), the Centro Nacional de Investigaciones Cardiovasculares (CNIC), and by the Ministerio de Economia, Industria y Competitividad (MEIC: SAF2013-44329-P, SAF2017-89299-P, and RYC-2013-13209). The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades (MCNU) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Sí |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink