Long-Term Intravesical Oxybutynin Chloride Therapy in Children with Myelodysplasia

Autor:	Timothy P. Bukowski, Andrew L. Freedman, Ricardo Gonzalez, Thomas S. Vates, Patricia Fleming, Alan D. Perlmutter, Craig Allen Smith, Kelly A. Painter
Rok vydání:	1996
Předmět:	Urinary bladder business.industry Urology Urodynamic studies Retrospective cohort study Mean age medicine.disease medicine.anatomical_structure Oxybutynin Chloride Anesthesia Oxybutynine Medicine business Neurogenic bladder dysfunction
Zdroj:	Journal of Urology. 156:1459-1462
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(01)65629-5
Popis:	Purpose: We evaluated the clinical use of long-term intravesical oxybutynin chloride in the treatment of neurogenic bladder dysfunction in children with myelodysplasia who could not tolerate oral anticholinergics.Materials and Methods: We retrospectively reviewed the records of all patients recommended for intravesical oxybutynin chloride therapy. A total of 12 girls and 18 boys 1 to 17 years old was recruited for study. Oxybutynin chloride (5 mg.) was instilled 2 times daily and pretreatment cystograms were compared to followup urodynamic studies. Duration of therapy was 2 to 26 months (mean 13, median 12).Results: Mean total capacity plus or minus standard deviation increased from 209 plus/minus 103 to 282 plus/minus 148 ml. (p less than 0.01), mean safe capacity increased from 157 plus/minus 105 to 234 plus/minus 147 ml. (p less than 0.01) and mean age adjusted safe capacity increased from 76 plus/minus 36 to 115 plus/minus 62 percent. Of the 29 patients who were incontinent 3 (10 percent) achi...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da576b06d100e4be6d84fb634644e8c https://doi.org/10.1016/s0022-5347(01)65629-5 Zobrazit plný text záznamu