Prolonged Neoadjuvant Therapy for Locally Advanced Pancreatic Cancer
| Autor: | Kunihito Gotoh, Hiroshi Wada, Koichi Kawamoto, Yuichiro Doki, Masahiro Tanemura, Taroh Satoh, Yoshifumi Iwagami, Hidetoshi Eguchi, Fumiaki Isohashi, Tadafumi Asaoka, Daisuke Sakai, Takehiro Noda, Daisaku Yamada, Toshihiro Kudo, Masaki Mori, Yutaka Takeda |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine Borderline resectable medicine Humans In patient Stage (cooking) Survival rate Neoadjuvant therapy Aged Neoplasm Staging Aged 80 and over business.industry Systemic chemotherapy General surgery Gastroenterology Chemoradiotherapy Adjuvant Middle Aged Neoadjuvant Therapy Surgery Locally advanced pancreatic cancer Pancreatic Neoplasms 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology business Chemoradiotherapy Carcinoma Pancreatic Ductal Follow-Up Studies |
| Zdroj: | Digestive Surgery. 35:70-76 |
| ISSN: | 1421-9883 0253-4886 |
| Popis: | Purpose: The purpose of this study was to investigate if prolonged neoadjuvant therapy, for locally advanced pancreatic cancer could be used to identify those patients who could benefit from resection surgery. Methods: Thirty-four patients with locally advanced pancreatic cancer invading the adjacent major arteries underwent chemoradiotherapy, followed by 6 months of systemic chemotherapy, unless their tumor was already resectable. After this combination treatment, surgical resection was performed on those patients with tumors judged to be at least borderline resectable. Results: Reevaluation after chemoradiotherapy revealed that, at that stage, surgery was only possible for one case; resection was successfully performed. Following 6 months of systemic chemotherapy, a further 7 patients were diagnosed with borderline resectable lesions; 4 underwent surgery with no postoperative complications. The median survival time of the patients following surgery was 3.63 years; this was reduced to approximately a third in patients not undergoing surgery (1.01 years; p = 0.0005). Conclusions: For patients with locally advanced pancreatic cancer, prolonged neoadjuvant therapy was successfully used to select candidates that could benefit from surgical resection of their tumor. Resection significantly increased the long-term survival rate. |
| Databáze: | OpenAIRE |
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