Differentially methylated DNA regions in early childhood wheezing: An epigenome‐wide study using saliva
| Autor: | Laura De Marco, Franca Rusconi, Maja Popovic, Anna Gillio-Tos, Morena Trevisan, Franco Merletti, Francesca Fasanelli, Chiara Grasso, Silvia Polidoro, Valentina Fiano, Daniela Zugna, Lorenzo Richiardi, Manuela Bianca Assumma |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Saliva Immunology Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine children medicine Humans Immunology and Allergy DMR EWAS PM20D1 asthma epigenetics epigenome-wide association study infant saliva wheezing Epigenetics Early childhood Respiratory Sounds 030304 developmental biology Asthma 0303 health sciences business.industry Infant Epigenome DNA Methylation medicine.disease 3. Good health Italy 030228 respiratory system CpG site Case-Control Studies Cord blood Pediatrics Perinatology and Child Health DNA methylation Female business Genome-Wide Association Study |
| Zdroj: | Pediatric Allergy and Immunology |
| ISSN: | 1399-3038 0905-6157 |
| DOI: | 10.1111/pai.13023 |
| Popis: | BACKGROUND Epigenetics may play a role in wheezing and asthma development. We aimed to examine infant saliva DNA methylation in association with early childhood wheezing. METHODS A case-control study was nested within the NINFEA birth cohort with 68 cases matched to 68 controls by sex, age (between 6 and 18 months, median: 10.3 months) and season at saliva sampling. Using a bumphunting region-based approach, we examined associations between saliva methylome measured using Illumina Infinium HumanMethylation450k array and wheezing between 6 and 18 months of age. We tested our main findings in independent publicly available data sets of childhood respiratory allergy and atopic asthma, with DNA methylation measured in different tissues and at different ages. RESULTS We identified one wheezing-associated differentially methylated region (DMR) spanning ten sequential CpG sites in the promoter-regulatory region of PM20D1 gene (family-wise error rate |
| Databáze: | OpenAIRE |
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