| Autor: |
Michelle R. Asbury, Sara Shama, Jong Yup Sa, Nicole Bando, James Butcher, Elena M. Comelli, Julia K. Copeland, Victoria Forte, Alex Kiss, Philip M. Sherman, Alain Stintzi, Amel Taibi, Christopher Tomlinson, Sharon Unger, Pauline W. Wang, Deborah L. O’Connor |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Cell Host & Microbe. 30:1328-1339.e5 |
| ISSN: |
1931-3128 |
| Popis: |
Nutrient fortifiers are added to human milk to support the development of very-low-birth-weight infants. Currently, bovine-milk-based fortifiers (BMBFs) are predominantly administered, with increasing interest in adopting human-milk-based fortifiers (HMBFs). Although beneficial for growth, their effects on the gastrointestinal microbiota are unclear. This triple-blind, randomized clinical trial (NCT02137473) tested how nutrient-enriching human milk with HMBF versus BMBF affects the gastrointestinal microbiota of infants born 1,250 g during hospitalization. HMBF-fed infants (n = 63, n = 269 stools) showed lower microbial diversity, altered microbial community structure, and changes in predicted microbial functions compared with BMBF-fed infants (n = 56, n = 239 stools). HMBF-fed infants had higher relative and normalized abundances of unclassified Enterobacteriaceae and lower abundances of Clostridium sensu stricto. Post hoc analyses identified dose-dependent relationships between individual feed components (volumes of mother's milk, donor milk, and fortifiers) and the microbiota. These results highlight how nutrient fortifiers impact the microbiota of very-low-birth-weight infants during a critical developmental window. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
