Pyrazole-O-glucosides as novel Na(+)-glucose cotransporter (SGLT) inhibitors

Autor:	Akiko Oonuki, Nobuo Kondo, Koji Ohsumi, Ryusuke Hirama, Nozomu Ishida, Toshihiro Hatanaka, Yoko Kageyama, Katsumi Maezono, Takashi Umemura, Hiroyuki Matsueda
Rok vydání:	2003
Předmět:	Brush border Monosaccharide Transport Proteins Clinical Biochemistry Pharmaceutical Science Rat kidney Na glucose cotransporter Pharmacology Pyrazole Inhibitory postsynaptic potential Kidney Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Sodium-Glucose Transporter 1 Glucoside Glucosides Glycosuria Drug Discovery medicine Structure–activity relationship Animals Hypoglycemic Agents Enzyme Inhibitors Rats Wistar Molecular Biology Membrane Glycoproteins Microvilli SGLT Inhibitors Organic Chemistry Kidney metabolism Biological activity General Medicine Rats medicine.anatomical_structure Glucose chemistry Injections Intravenous Molecular Medicine Pyrazoles Indicators and Reagents
Zdroj:	Bioorganicmedicinal chemistry letters. 13(14)
ISSN:	0960-894X
Popis:	O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [(14)C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da104992cd8d046dcd61f74a0fb71ba https://pubmed.ncbi.nlm.nih.gov/12824015 Zobrazit plný text záznamu Full Text from ScienceDirect