Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease
| Autor: | Mustafa Ozsahin, Mehmet Şahin, Fatih Ermis, Ali Kutlucan, Sevket Ercan Tunc, Recep Sutcu, Davut Baltaci, Harun Süslü |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Dicle Medical Journal, Vol 39, Iss 3, Pp 325-330 (2012) |
| ISSN: | 1308-9889 1300-2945 |
| Popis: | Objectives: Osteoporosis is commonly developed due tonatural course of Behçet’s disease (BD) and therapeuticagents. It was aimed to investigate levels of osteoprotegerinand TNF-α (tumor necrosis factor), and bone mineral density(BMD) and correlation between them in BD.Materials and methods: The study included two groupsas the study and the control group. Serum levels of TNF-α,osteoprotegerin, osteocalcine, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP), and urinary creatinine anddeoxypyridinoline along with BMD level were evaluated andcompared. Correlation between TNF-α and osteoprotegerinlevel was investigated.Results: The study enrolled 41 BD patients and 36 agedmatchedcontrol subjects. Mean age was 42.26±11.64 and41.66±70.99, in the study and control groups, respectively.There was no significant difference in body mass index(BMI) of subjects between groups (p>0.05). Level of TNF-α(p0.05).Urinary deoxypyridinoline/ urinary creatinine ratio in patientswith BD was significantly higher than those in control group(p=0.030). Patients had significantly lower BMD comparfedto the control group, except L2-L4 vertebral area (p |
| Databáze: | OpenAIRE |
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