Predictive criteria of severe cases in COVID‐19 patients of early stage: A retrospective observational study

Autor: Haibo Gu, Xiu Huang, Lingyun Lou, Zhihao Xu, Jinrui Gao
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Clinical Biochemistry
Disease
Logistic regression
SARS‐CoV‐2
0302 clinical medicine
Risk Factors
Immunology and Allergy
Medicine
Stage (cooking)
Alanine aminotransferase
Research Articles
Hematology
Middle Aged
Medical Laboratory Technology
030220 oncology & carcinogenesis
cytokine storm
Female
Coronavirus Infections
Cytokine Release Syndrome
Research Article
Microbiology (medical)
Adult
medicine.medical_specialty
China
Coronavirus disease 2019 (COVID-19)
Critical Illness
Pneumonia
Viral
Early detection
03 medical and health sciences
Betacoronavirus
COVID‐19
Predictive Value of Tests
Internal medicine
Humans
Pandemics
Aged
Retrospective Studies
Biochemistry
medical
business.industry
SARS-CoV-2
Biochemistry (medical)
Public Health
Environmental and Occupational Health
COVID-19
Retrospective cohort study
medicine.disease
Pneumonia
030104 developmental biology
Early Diagnosis
business
laboratory parameter
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
Popis: Background Patients with coronavirus disease 2019 (COVID‐19) often suffer sudden deterioration of disease around 1‐2 weeks after onset. Once the disease progressed to severe phase, clinical prognosis of patients will significantly deteriorate. Methods This was a multicenter retrospective study on patients of all adult inpatients (≥18 years old) from Tianyou Hospital (Wuhan, China) and the Fourth Affiliated Hospital, Zhejiang University School of Medicine. All 139 patients had laboratory‐confirmed COVID‐19 in their early stage, which is defined as within 7 days of clinical symptoms. Univariate and multivariate logistic regression models were used to determine the predictive factors in the early detection of patients who may subsequently develop into severe cases. Results Multivariable logistic regression analysis showed that the higher level of hypersensitivity C‐reactive protein (OR = 4.77, 95% CI:1.92‐11.87, P = .001), elevated alanine aminotransferase (OR = 6.87, 95%CI:1.56‐30.21, P = .011), and chronic comorbidities (OR = 11.48, 95% CI:4.44‐29.66, P
Early COVID‐19 patients with chronic comorbidities, elevated hs‐CRP or increased ALT are significantly more likely to develop severe pneumonia as disease progresses
Databáze: OpenAIRE
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