Left ventricular apical pacing in children: feasibility and long-term effect on ventricular function
| Autor: | Viktor Tomek, Peter Kubuš, Shin Ono, Jan Janoušek, Miroslav Ložek, Jan Kovanda |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) Heart disease Heart Ventricles Ventricular Function Left Ventricular Dysfunction Left Oxygen Consumption Interquartile range Physiology (medical) Internal medicine medicine Humans Term effect Systole Child Ejection fraction business.industry Cardiac Pacing Artificial VO2 max Stroke Volume medicine.disease Oxygen Child Preschool Cardiology Feasibility Studies Cardiology and Cardiovascular Medicine business Atrioventricular block |
| Zdroj: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 22(2) |
| ISSN: | 1532-2092 |
| Popis: | Aims Left ventricular apical pacing (LVAP) has been reported to preserve left ventricular (LV) function in chronically paced children with complete atrioventricular block (CAVB). We sought to evaluate long-term feasibility of LVAP and the effect on LV mechanics and exercise capacity as compared to normal controls. Methods and results Thirty-six consecutive paediatric patients with CAVB and LVAP in the absence (N = 22) or presence of repaired structural heart disease (N = 14, systemic LV in all) and 25 age-matched normal controls were cross-sectionally studied after a median of 3.9 (interquartile range 2.1–6.8) years of pacing using echocardiography and exercise stress testing. Pacemaker implantation was uneventful and there was no death. Probability of the absence of pacemaker-related surgical revision (elective generator replacement excluded) was 89.0% at 5 years after implantation. Left ventricular apical pacing patients had lower maximum oxygen uptake (P = 0.009), no septal to lateral but significant apical to basal LV mechanical delay (P Conclusion Left ventricular apical pacing is technically feasible with a low reintervention rate. Mechanical synchrony between LV septum and free wall is maintained at the price of an apical to basal mechanical delay associated with LV contraction inefficiency as compared to healthy controls. Global LV systolic function is, however, not negatively affected by LVAP. |
| Databáze: | OpenAIRE |
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