Isolation and propagation of nephropathia epidemica virus in bank voles
| Autor: | Dmitry Goldgaber, D. Carleton Gajdusek, Clarence J. Gibbs, Kurtny Ström, Richard Yanagihara, Herbert L. Amyx, Pyung-Woo Lee, Arne Svedmyr |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Microbiology (medical)
Orthohantavirus Rodent Physiology Fluorescent Antibody Technique Virus Epitopes Physiology (medical) biology.animal Nephropathia epidemica medicine Animals Humans RNA Viruses Antigens Viral Lung Subclinical infection Disease Reservoirs Sweden General Immunology and Microbiology biology Nephropathia epidemica virus Host (biology) Arvicolinae General Medicine biology.organism_classification medicine.disease Isolation (microbiology) Virology Infectious Diseases Hemorrhagic Fever with Renal Syndrome Vole |
| Zdroj: | Scandinavian journal of infectious diseases. 16(3) |
| ISSN: | 0036-5548 |
| Popis: | Three strains of nephropathia epidemica (NE) virus were isolated from lung tissues of bank voles (Clethrionomys glareolus) and a grey-sided vole (C. rufocanus) trapped in Vasterbotten county, Sweden. Two of these isolates were serially passaged in seronegative laboratory-bred bank voles. Experimentally infected animals developed a subclinical infection characterized by virus persistence, particularly in lung tissue. Attempts to infect other species of colonized rodents with NE virus and to isolate NE virus from acute phase patient blood were unsuccessful. The serial propagation of NE virus in colonized bank voles provides opportunities to study experimental infection in its reservoir rodent host. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|