Rosmarinic acid administration attenuates diabetes-induced vascular dysfunction of the rat aorta
| Autor: | Ruzena Sotnikova, L. Pivackova, Peter Krenek, Beata GajdacovaB. Gajdacova, Jana Navarová, Jana Vlkovicova, Silvia Fialová, Ludmila Okruhlicova |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Necrosis Antioxidant Endothelium medicine.medical_treatment Interleukin-1beta Pharmaceutical Science Endothelin-Converting Enzymes Pharmacology medicine.disease_cause Depsides Antioxidants Diabetes Mellitus Experimental Diabetes Complications chemistry.chemical_compound medicine.artery Animals Aspartic Acid Endopeptidases Medicine Vascular Diseases Rats Wistar Aorta Lamiaceae Endothelin-1 Tumor Necrosis Factor-alpha business.industry Rosmarinic acid Metalloendopeptidases Rats Vasodilation Streptozocin medicine.anatomical_structure chemistry Biochemistry Cinnamates Endothelium Vascular medicine.symptom business Endothelin receptor Oxidative stress Phytotherapy |
| Zdroj: | Journal of Pharmacy and Pharmacology. 65:713-723 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | Objectives Oxidative stress as well as inflammation processes are engaged in diabetic vascular complications. Rosmarinic acid, a natural phenol antioxidant carboxylic acid, was found to have multiple biological activity, including anti-inflammatory and antitumour effects, which are a consequence of its inhibition of the inflammatory processes and of reactive oxygen species scavenging. The aim of this work was to study effects of rosmarinic acid administration on vascular impairment induced by experimental diabetes in rats. Methods Diabetes was induced by streptozocin (3 × 30 mg/kg daily, i.p.) in Wistar rats. Rosmarinic acid was administered orally (50 mg/kg daily). Ten weeks after streptozocin administration, the aorta was excised for functional studies, evaluation by electron microscopy and real time PCR analysis. Key findings In the aorta of diabetic rats, decreased endothelium-dependent relaxation was accompanied by overexpression of interleukin-1β, tumour necrosis factor-α, preproendothelin-1 and endothelin converting enzyme-1. Structural alterations in the endothelium, detected by electron microscopy, indicated aortic dysfunction caused by diabetes. The diabetes-induced aortic disorders were prevented by rosmarinic acid administration. Conclusions Rosmarinic acid protected aortic endothelial function and ultrastructure against diabetes-induced damage. Both antioxidant and anti-inflammatory effects of rosmarinic acid seemed to participate in the mechanism of this protection. |
| Databáze: | OpenAIRE |
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