Enhanced spectrophotometric determination of Losartan potassium based on its physicochemical interaction with cationic surfactant
| Autor: | Lobna Abdel-Aziz, Laila Abdel-Fattah, Mariam Gaied |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Losartan Potassium
Chemical Phenomena Inorganic chemistry Micelle Losartan Acid dissociation constant Analytical Chemistry Surface-Active Agents chemistry.chemical_compound Pulmonary surfactant Bromide Cations Instrumentation Micelles Spectroscopy Cetrimonium Chemistry Cationic polymerization Binding constant Atomic and Molecular Physics and Optics Partition coefficient Spectrophotometry Calibration Cetrimonium Compounds Spectrophotometry Ultraviolet Tablets Nuclear chemistry |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 136:178-184 |
| ISSN: | 1386-1425 |
| DOI: | 10.1016/j.saa.2014.09.007 |
| Popis: | In this study, a simple and sensitive spectrophotometric method was developed for determination of Losartan potassium (LST K), an angiotensin-II receptor (type AT1) antagonist, in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB). The physicochemical interaction of LST K with CTAB was investigated. The effect of cationic micelles on the spectroscopic and acid–base properties of LST K was studied at pH 7.4. The binding constant (Kb) and the partition coefficient (Kx) of LST K-CTAB were 1.62 × 105 M−1 and 1.38 × 105; respectively. The binding of LST K to CTAB micelles implied a shift in drug acidity constant (ΔpKa = 0.422). The developed method is linear over the range 0.5–28 μg mL−1. The accuracy was evaluated and was found to be 99.79 ± 0.509% and the relative standard deviation for intraday and interday precision was 0.821 and 0.963; respectively. The method was successfully applied to determine LST K in pharmaceutical formulations. |
| Databáze: | OpenAIRE |
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