Heart rate variability and n-3 polyunsaturated fatty acids in patients with diabetes mellitus

Autor: H. Aarup Skou, J. Hagtrup Christensen, E. Berg Schmidt, Trine Madsen, I. Tørring
Rok vydání: 2001
Předmět:
Zdroj: Journal of Internal Medicine. 249:545-552
ISSN: 1365-2796
0954-6820
DOI: 10.1046/j.1365-2796.2001.00841.x
Popis: Hagstrup Christensen J, Aarup Skou H, Madsen T, Torring I, Berg Schmidt E (Aalborg Hospital, Aalborg; and Hjorring/Bronderslev Hospital, Hjorring, Denmark). Heart rate variability and n-3 polyunsaturated fatty acids in patients with diabetes mellitus. J Intern Med 2001; 249: 545–552. Objectives. Dietary n-3 polyunsaturated fatty acids (PUFA) derived from fish may reduce the incidence of sudden cardiac death (SCD). The aim of the present study was to examine associations between n-3 PUFA and 24-h heart rate variability in patients with type 1 and type 2 diabetes mellitus (DM). Design. Observational study. Setting. The out-patient’s diabetic clinic at Hjorring Hospital, Hjorring, Denmark. Subjects. Forty-three patients with type 1 DM and 38 patients with type 2 DM. Main outcome measures. The patients fulfilled a food-questionnaire regarding fish consumption, whilst the content of n-3 PUFA in platelets was measured and 24-h heart rate variability (HRV) was obtained. Results. The patients fish consumption was strongly related to their content of n-3 PUFA in platelets. Furthermore, in patients with type 1 DM a close positive association was found between the content of n-3 PUFA in platelets and 24-h HRV. This association was not significant in patients with type 2 DM. Conclusions. The positive association between n-3 PUFA in platelets and HRV may indicate a beneficial effect of n-3 PUFA on HRV in patients with type 1 DM. Further studies are warranted to clarify whether supplementation with n-3 PUFA reduce the risk of SCD amongst patients with DM.
Databáze: OpenAIRE
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