Recent advances on HIV DNA vaccines development: Stepwise improvements to clinical trials
| Autor: | Behzad Baradaran, Saeed Khalili, Miguel de la Guardia, Ahad Mokhtarzadeh, Jafar Mosafer, Tayebeh Rezaei, Sarah Rezaei |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmaceutical Science
HIV Infections 02 engineering and technology Virus DNA vaccination 03 medical and health sciences Immune system Acquired immunodeficiency syndrome (AIDS) Antigen Adjuvants Immunologic medicine Vaccines DNA Animals Humans Vector (molecular biology) 030304 developmental biology AIDS Vaccines 0303 health sciences Clinical Trials as Topic Immunity Cellular business.industry Vaccination 021001 nanoscience & nanotechnology medicine.disease Immunity Humoral Clinical trial Immunology 0210 nano-technology business |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 316 |
| ISSN: | 1873-4995 |
| Popis: | According to WHO (World Health Organization) reports, more than 770,000 people died from HIV and almost 1.7 million people becoming newly infected in the worldwide in 2018. Therefore, many attempts should be done to produce a forceful vaccine to control the AIDS. DNA-based vaccines have been investigated for HIV vaccination by researches during the recent 20 years. The DNA vaccines are novel approach for induction of both type of immune responses (cellular and humoral) in the host cells and have many advantages including high stability, fast and easy of fabrication and absence of severe side effects when compared with other vaccination methods. Recent studies have been focused on vaccine design, immune responses and on the use of adjuvants as a promising strategy for increased level of responses, delivery approaches by viral and non-viral methods and vector design for different antigens of HIV virus. In this review, we outlined the aforementioned advances on HIV DNA vaccines. Then we described the future trends in clinical trials as a strong strategy even in healthy volunteers and the potential developments in control and prevention of HIV. |
| Databáze: | OpenAIRE |
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