Lack of effect of donor-recipient ABO mismatching on outcome following allogeneic hematopoietic stem cell transplantation
| Autor: | Robert Emmons, Mangan Kf, John Ulicny, Mary Ellen Martin, Jay H. Herman, Thomas R. Klumpp |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Time Factors medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation Disease-Free Survival ABO Blood-Group System Donor Selection Recurrence ABO blood group system Neoplasms Medicine Humans Transplantation Homologous Progenitor cell Risk factor Retrospective Studies Transplantation business.industry Remission Induction Hematopoietic Stem Cell Transplantation Hematopoietic stem cell Hematology medicine.disease Tissue Donors surgical procedures operative medicine.anatomical_structure Graft-versus-host disease Blood Grouping and Crossmatching Immunology Female Stem cell business |
| Zdroj: | Bone marrow transplantation. 38(9) |
| ISSN: | 0268-3369 |
| Popis: | Several recently published studies have suggested that patients who undergo ABO mismatched hematopoietic stem cell transplantation may be at increased risk for relapse, graft-versus-host disease, transplant-related mortality, and/or all-cause mortality. To investigate this issue further, we analyzed potential associations between the donor-recipient ABO mismatch pattern and the above outcome measures among 240 consecutive patients who underwent allogeneic hematopoietic stem cell transplantation at our institution. Our analyses uncovered no significant associations between donor-recipient ABO mismatch pattern and overall survival, event-free survival, transplant-related mortality, incidence of acute graft-versus-host disease (GVHD), or incidence of chronic GVHD. Our data do not support recent assertions that donor-recipient ABO mismatching is a major risk factor for patients undergoing allogeneic transplant, nor do they support recent assertions that ABO matching should be an important consideration in selecting allogeneic hematopoietic stem cell donors. |
| Databáze: | OpenAIRE |
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