The efficacy of inhaled nitric oxide treatment in premature infants with acute pulmonary hypertension
| Autor: | Badr Chaban, Dimitrios Rallis, Gaurav Atreja, Jayanta Banerjee, Aniko Deierl |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Pulmonary Oligohydramnios Gestational Age Infant Premature Diseases Nitric Oxide Gastroenterology Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030225 pediatrics Internal medicine Administration Inhalation Medicine Humans 030212 general & internal medicine Survival rate Retrospective Studies business.industry Infant Newborn Obstetrics and Gynecology Retrospective cohort study medicine.disease Pulmonary hypertension Survival Rate Positive response Treatment Outcome chemistry Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Cohort Female business Infant Premature |
| Zdroj: | Early human development. 127 |
| ISSN: | 1872-6232 |
| Popis: | Although inhaled nitric oxide (iNO) therapy in term infants with pulmonary hypertension (PHT) has demonstrated definite benefit, the use of iNO in preterm infants remains inconclusive.To evaluate the impact of iNO treatment in premature infants with acute PHT.Retrospective cohort.Infants 34 weeks' gestational age, admitted during 2010-2016 to two neonatal units, having treated with iNO for confirmed PHT. A positive response was defined by FiOThe primary outcome was the evaluation of the acute response to iNO administration. Secondary outcomes included the comparison of neonatal characteristics and outcomes between positive and negative responders, and early or late PHT infants.Of the 55 infants of our cohort, 39 (71%) had a positive response to iNO administration. No differences noted regarding bronchopulmonary dysplasia, intraventricular haemorrhage or other morbidities; however, positive responders had significantly higher survival rate in overall (77 vs 21%, p = 0.001) and within early PHT subgroup (74 vs 33%, p = 0.044). Regression analysis revealed that oligohydramnios (OR 2.834, 95%CI 1.652-6.070) and early PHT (OR 1.953, 95%CI 1.377-2.930) were significantly related with a positive response.Preterm infants with confirmed acute PHT respond in significant proportion to the iNO administration, especially in the background of oligohydramnios or the development of early PHT. |
| Databáze: | OpenAIRE |
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