Genes involved in senescence and immortalization
| Autor: | Ante S. Lundberg, Robert A. Weinberg, Piyush Gupta, William C. Hahn |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Senescence
Cell Cell Physiological Processes Biology Mice Tumor Suppressor Protein p14ARF medicine Animals Humans Gene Cellular Senescence Regulation of gene expression Oncogene Activation Genes p16 Proteins Oncogenes Cell Biology Telomere Phenotype Cell biology Oxidative Stress medicine.anatomical_structure Gene Expression Regulation Reactive Oxygen Species Cell Division Signal Transduction |
| Zdroj: | Current Opinion in Cell Biology. 12:705-709 |
| ISSN: | 0955-0674 |
| DOI: | 10.1016/s0955-0674(00)00155-1 |
| Popis: | Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization. |
| Databáze: | OpenAIRE |
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