Increased mean platelet volume is associated with arterial stiffness

Autor:	Xiu-Ying Zhu, Rui-tao Wang, Ying Li, Yi-Na Zhang
Rok vydání:	2011
Předmět:	Adult Blood Glucose Blood Platelets Male medicine.medical_specialty China Brachial Artery Blood Pressure Body Mass Index chemistry.chemical_compound High-density lipoprotein Vascular Stiffness Risk Factors Internal medicine medicine Humans Platelet activation Mean platelet volume Pulse wave velocity Cell Size business.industry Hematology General Medicine Arteriosclerosis Middle Aged medicine.disease Lipoproteins LDL Endocrinology Blood pressure Cross-Sectional Studies chemistry Research Design Population Surveillance Multivariate Analysis Cardiology Arterial stiffness Female Vascular Resistance Ankle business Lipoproteins HDL Body mass index Blood Flow Velocity
Zdroj:	Platelets. 22(6)
ISSN:	1369-1635
Popis:	The brachial-ankle pulse wave velocity (baPWV) is a useful index of arterial stiffness. Mean platelet volume (MPV), an indicator of platelet activation, is associated with hypertension, stroke, and coronary artery disease, all of which may be caused by arteriosclerosis. However, little research has been conducted to investigate the relationship between MPV and arterial stiffness. In this cross-sectional study, we investigated the relationship between platelet count, MPV, and baPWV in 2645 apparently healthy Chinese participants (1676 men, 969 women) in a general health examination. Different metabolic parameters were compared across MPV quintiles (Q1: ≤8.1 fl, Q2: 8.2-8.5 fl, Q3: 8.6-9.6 fl, Q4: 9.7-10.7 fl, and Q5: ≥10.8 fl). Age-adjusted mean values of baPWV gradually increased with MPV quintiles (Q1 = 1124, Q2 = 1134, Q3 = 1199, Q4 = 1207, and Q5 = 1270 cm/s). Univariate analysis showed that age, sex, smoking status, body mass index (BMI), systolic blood pressure (SBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), total platelet count, and MPV were significantly associated with baPWV. In addition, age, sex, BMI, MPV, SBP, and FPG were significant factors in the multivariate model with baPWV. Notably, MPV was found to be a significant determinant for baPWV (β = 0.198; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d955704aaa6b74487b070a8369c2747 https://pubmed.ncbi.nlm.nih.gov/21473674 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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