Pro12ala Gene Polymorphism in the Peroxisome Proliferator-Activated Receptor Gamma as a Risk Factor for the Onset of Type 2 Diabetes Mellitus in the Serbian Population

Autor:	Z. Andjelkovic, M. Sumarac-Dumanovic, Tamara Djurić, Aleksandra Stanković, Dragan Alavantić, Maja Zivkovic, P. Ristic, Sanja Soskic
Rok vydání:	2010
Předmět:	medicine.medical_specialty insulin endocrine system diseases type 2 diabetes mellitus medicine.medical_treatment Population Peroxisome proliferator-activated receptor 030209 endocrinology & metabolism General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Allele Risk factor education lcsh:QH301-705.5 030304 developmental biology chemistry.chemical_classification 0303 health sciences education.field_of_study PPAR gamma(2) business.industry Insulin Type 2 Diabetes Mellitus nutritional and metabolic diseases 3. Good health Endocrinology lcsh:Biology (General) chemistry PPARγ2 Population study Pro12Ala polymorphism Gene polymorphism General Agricultural and Biological Sciences business
Zdroj:	Archives of Biological Sciences Archives of Biological Sciences, Vol 62, Iss 2, Pp 263-270 (2010)
Popis:	The peroxisome proliferator-activated receptor gamma (PPAR?) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPAR? Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 controls and 163 T2DM patients. The 12Ala allele tended to be more frequent in the group of T2DM patients (0.11) compared to the control subjects (0.09). The results from this study indicate that the PPAR?2 12Ala allele presents a non-significant risk factor for T2DM development in the Serbian population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d94b7f4123358e97553274db265e3e4 https://vinar.vin.bg.ac.rs/handle/123456789/4047 Zobrazit plný text záznamu