Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis
| Autor: | Seniha Aktakka, Nazime Sen, Arzu Duran, Senol Kobak, Mehmet Orman, Tennur Atabay |
|---|---|
| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Delayed Diagnosis calprotectin Gastroenterology Inflammatory bowel disease Feces 0302 clinical medicine fluids and secretions BASDAI HLA-B27 Antigen lcsh:R5-920 medicine.diagnostic_test biology Anthropometry General Medicine Middle Aged C-Reactive Protein Erythrocyte sedimentation rate Biomarker (medicine) Female lcsh:Medicine (General) Research Article Ankylosing spondylitis Adult medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Blood Sedimentation 03 medical and health sciences Internal medicine medicine Humans Spondylitis Ankylosing 030203 arthritis & rheumatology BASFI business.industry C-reactive protein medicine.disease Inflammatory Bowel Diseases 030104 developmental biology Case-Control Studies Immunology biology.protein Calprotectin business Leukocyte L1 Antigen Complex disease activity Biomarkers |
| Zdroj: | Bosnian Journal of Basic Medical Sciences, Vol 16, Iss 1 (2016) |
| Popis: | WOS: 000369625200012 PubMed ID: 26773186 Calprotectin is one of the major antimicrobial S100 leucocyte proteins. Serum calprotectin levels are associated with certain inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease. The aim of this study was to investigate serum and fecal calprotectin levels in patients with ankylosing spondylitis (AS) and show their potential relations to the clinical findings of the disease. Fifty-one patients fulfilling the New York criteria of AS and 43 healthy age- and gender-matched volunteers were included in the study. Physical and locomotor system examinations were performed and history data were obtained for all patients. Disease activity parameters were assessed together with anthropometric parameters. Routine laboratory examinations and genetic testing (HLA-B-27) were performed. Serum calprotectin levels and fecal calprotectin levels were measured by an enzyme-linked immunosorbent assay. The mean age of the patients was 41.5 years, the mean duration of the disease was 8.6 years, and the delay in diagnosis was 4.2 years. Serum calprotectin levels were similar in both AS patients and in the control group (p=0.233). Serum calprotectin level was correlated with Bath AS disease activity index (BASDAI) and Bath AS functional index (BASFI) (p=0.001, p=0.002, respectively). A higher level of fecal calprotectin was detected in AS patients when compared with the control group. A statistically significant correlation between fecal calprotectin level and BASDAI, BASFI, C-reactive protein and Erythrocyte sedimentation rate were detected (p=0.002, p=0.005, p=0.001, p=0.002, respectively). The results indicated that fecal calprotectin levels were associated with AS disease findings and activity parameters. Calprotectin is a vital disease activity biomarker for AS and may have an important role in the pathogenesis of the disease. Multi-centered prospective studies are needed in order to provide further insight. |
| Databáze: | OpenAIRE |
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