Increased urinary catechol estrogen excretion in female smokers
| Autor: | H. Leon Bradlow, Jon J. Michnovicz, Jack Fishman, Richard J. Hershcopf, Hiroshi Naganuma |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Urinary system media_common.quotation_subject Clinical Biochemistry Radioimmunoassay Estrone Urine Biochemistry Excretion chemistry.chemical_compound Endocrinology Internal medicine Follicular phase medicine Humans Radiometry Molecular Biology Menstrual cycle media_common Pharmacology Estradiol Smoking Organic Chemistry Estriol Estrogens Catechol Steroid 16-alpha-Hydroxylase chemistry Estrogen Female |
| Zdroj: | Steroids. 52:69-83 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(88)90218-8 |
| Popis: | Premenopausal female smokers show significantly increased estrogen 2-hydroxylation, which may account in part for the anti-estrogenic effects of cigarette smoking. We have measured five major urinary estrogens, including estradiol (E2), estrone (E1), 16 alpha-hydroxyestrone (16 alpha OHE1), estriol (E3), and 2-hydroxyestrone (2OHE1), in premenopausal female smokers and non-smokers, to determine whether increased C-2 hydroxylation affected the urinary excretory patterns in these subjects. While total measured estrogen excretion in the follicular phase did not differ significantly between the two groups, urinary 2OHE1 among the smokers constituted a significantly greater proportion of the total (31.1 vs 18.2%, P less than 0.02). This difference was largely caused by significantly increased urinary 2OHE1 and decreased E3 observed in smokers. A urinary catechol estrogen index, defined by [2OHE1]/[E3], was significantly elevated in smokers compared with non-smokers (1.67 +/- 0.21 vs 0.56 +/- 0.08, P less than 0.001), and this urinary index correlated strongly with radiometrically determined estrogen 2-hydroxylation (r = 0.84, P less than 0.01). Ratios of the various estrogen metabolites did not vary substantially throughout the menstrual cycle. Urinary estrogen indices as described here may therefore be useful in demonstrating differences in estrogen metabolism, specifically 2-hydroxylation vs 16 alpha-hydroxylation, in selected populations. |
| Databáze: | OpenAIRE |
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