Clinical and laboratory evaluation of cured and non-cured patients with cutaneous leishmaniasis treated by Glucantime
| Autor: | Behnaz Aflatoonian, F. Zolala, Alireza Kermanizadeh, Iraj Sharifi, Zahra Babaei, Mehdi Bamorovat, Ebrahim Saedi Dezaki, Mohammad Reza Baneshi, F. Ezatkhah, Alireza Keyhani, Mohamad Reza Aflatoonian, Mehrdad Khatami, Maryam Sharifi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Antiprotozoal Agents Leishmaniasis Cutaneous Gastroenterology lcsh:Infectious and parasitic diseases Young Adult Cutaneous leishmaniasis Age groups Untreated control Internal medicine cutaneous leishmaniasis glucantime unresponsiveness in vitro evaluation Ic50 values medicine Humans lcsh:RC109-216 Amastigote Child Leishmania major Meglumine Antimoniate business.industry Macrophages Leishmaniasis General Medicine medicine.disease Infectious Diseases Cross-Sectional Studies Treatment Outcome Child Preschool Therapeutic failure Antimonial Drug Evaluation Parasitology Female business |
| Zdroj: | Journal of Vector Borne Diseases, Vol 56, Iss 4, Pp 351-359 (2019) |
| ISSN: | 0972-9062 |
| Popis: | Background & objectives: Insufficient treatment of cutaneous leishmaniasis (CL) by conventional drugs is a major barrier in control strategies. This study was aimed to evaluate Glucantime efficacy and the susceptibility of Glucantime unresponsive and responsive CL isolates in the field and laboratory. Methods: Chi-square test (x[2]) was used to determine the significance of difference between proportions in Glucantime-treated patients. The inhibitory activity of various concentrations of Glucantime against Leishmenia tropica stages was evaluated by a colorimetric cell viability MTT and macrophage assays. Mixed model, t-test and ANOVA were performed to determine the significance of difference between various concentrations of Glucantime unresponsive or responsive isolates and untreated control group and p |
| Databáze: | OpenAIRE |
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