Perinatal BPA exposure and reproductive axis function in CD-1 mice
| Autor: | Ana M. Soto, Beverly S. Rubin, Cheryl M. Schaeberle, Nicole Acevedo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Anti-Mullerian Hormone Male medicine.medical_specialty endocrine system media_common.quotation_subject Fertility Estrous Cycle Gonadotropin-releasing hormone Biology Endocrine Disruptors Toxicology Article Gonadotropin-Releasing Hormone 03 medical and health sciences Mice Phenols Pregnancy Internal medicine Follicular phase medicine Animals Benzhydryl Compounds Maternal-Fetal Exchange media_common Estrous cycle Neurons Perinatal Exposure urogenital system Estrogens Luteinizing Hormone Fecundity 030104 developmental biology Endocrinology Female Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 79 |
| ISSN: | 1873-1708 |
| Popis: | Perinatal Bisphenol-A (BPA) exposure reduces fertility and fecundity in mice. This study examined effects of early BPA exposure on activation of gonadotropin releasing hormone (GnRH) neurons in conjunction with a steroid-induced luteinizing hormone (LH) surge, characterized patterns of estrous cyclicity and fertility over time, and assessed the ovarian follicular reserve to further explore factors responsible for the reduced fertility we previously described in this model. The percent activated GnRH neurons was reduced in BPA-exposed females at 3-6 months, and periods of persistent proestrus were increased. These data suggest that perinatal exposure to BPA reduces GnRH neuronal activation required for the generation of the LH surge and estrous cyclicity. Assessments of anti-Mullerian hormone (AMH) levels failed to suggest a decline in the follicular reserve at the BPA exposure levels examined. |
| Databáze: | OpenAIRE |
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