Determining the predictive capability of a Clinical Assessment Scoring Chart to differentiate severity of the clinical consequences of neonatal calf diarrhea relative to gold-standard blood gas analysis
| Autor: | Emer Kennedy, Riona Sayers, Patrick Dillane, Gearóid P. Sayers, Lea Krump |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Physiology Predictive capability Anion gap Pathology and Laboratory Medicine Severity of Illness Index Infographics Electrolytes Software Design Medicine and Health Sciences Electrochemistry Dehydration (Medicine) Diagnostic Techniques and Procedures Acidosis Multidisciplinary Dehydration Prognosis Charts Body Fluids Diarrhea Chemistry Blood blood gas analysis Veterinary Diseases Research Design Physical Sciences Medicine Female medicine.symptom Anatomy General Agricultural and Biological Sciences clinical assesment scoring chart Research Article medicine.medical_specialty Computer and Information Sciences Science Cattle Diseases Gastroenterology and Hepatology Signs and Symptoms Chart Predictive Value of Tests Diagnostic Medicine Internal medicine medicine Animals Receiver operating characteristic business.industry Data Visualization Chemical Compounds Biology and Life Sciences Gold standard (test) neonatal calf diarrhea Bicarbonates Animals Newborn Base excess Cattle Veterinary Science business |
| Zdroj: | e0230708 PLoS ONE PLoS ONE, Vol 15, Iss 4, p e0230708 (2020) |
| Popis: | peer-reviewed Neonatal calf diarrhea (NCD) is a major problem to calf health worldwide, in terms of both morbidity and mortality. A five-point ordinal scale clinical assessment scoring (CAS) chart was utilized to assess calves suffering from NCD-related clinical abnormalities (acidosis and dehydration) on commercial farms. The objective of this research was to determine the predictive capability of this CAS chart against gold standard blood gas parameters, designed to assist farmers in the accurate assessment of the clinical consequences of NCD. A total of 443 diarrheic and non-diarrheic calves were enrolled in the study. The CAS chart rated a calf’s health from no clinical signs to varying degrees of clinical severity on a 0 (clinically normal) to 4 (grave) scale, based on clinical indicators including calf demeanour, ear position, mobility, suckle reflex, desire-to-feed, and enophthalmos. Blood gas analysis was conducted for individual calves, consisting of pH, base excess, Na+, K+, Ca2+, Cl−, glucose, total hemoglobin, bicarbonate, anion gap, and strong ion difference. Statistical evaluation was performed by comparison of the CAS score with blood gas profiles using ordinal logistic regression and a non-parametric estimation of the Receiver Operating Characteristics (ROC). The ROC analysis indicated that the CAS chart had acceptable specificity (>95%) with low sensitivity (80%) but had reduced accuracy in differentiating mild and moderate cases (peak estimations >50%). The chart, as presented, provides a simple tool to differentiate clinically normal from calves suffering the consequences of diarrhea, but fails to accurately differentiate severity for NCD related acidosis and dehydration. Further efforts are required to enhance the sensitivity and differential diagnostic value of this type of chart. |
| Databáze: | OpenAIRE |
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