Combination chemotherapy without cisplatin in the treatment of advanced non-small cell lung cancer
| Autor: | Didier Choma, Xavier Quantin, William Jacot, Farid Khial, Jean-Louis Pujol |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Bridged-Ring Compounds Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Vinblastine Deoxycytidine chemistry.chemical_compound Quality of life Internal medicine Carcinoma Non-Small-Cell Lung Antineoplastic Combined Chemotherapy Protocols medicine Humans Lung cancer Cisplatin Chemotherapy business.industry Combination chemotherapy Vinorelbine medicine.disease Gemcitabine Surgery Survival Rate Paclitaxel chemistry Docetaxel Toxicity Quality of Life Taxoids business medicine.drug |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 38 |
| ISSN: | 0169-5002 |
| Popis: | Cisplatin-based combinations are standard regimens in the treatment of advanced non-small cell lung cancer. Survival improvement has been achieved using this therapy. However, the high toxicity induced by cisplatin-based doublets urges the research of alternate treatments. Newest cytotoxic compounds yield a better efficacy-toxicity ratio. Platinum-free doublet regimens based on new drugs are expected to offer the patient an improved survival without decreasing his quality of life. Treatment-allocated time and period with high grade toxicity could be considered as wasted from the patient point of view. QUALY methods based on time without symptoms and toxicity allow the accurate evaluation of this end-point. This brief state-of-the-art deals with methodological statements highlighted by the first publications of randomized studies comparing non-platinum-based doublets with either single-drug chemotherapy or standard cisplatin-based doublets. |
| Databáze: | OpenAIRE |
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