Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract
| Autor: | Yow-Heng Chen, Robert Kuo-Kuang Lee, Shau-Ping Lin, Yuan-Jang Tsai |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Platelet-derived growth factor DNA Complementary medicine.medical_treatment Molecular Sequence Data Biophysics Uterus Endothelial Growth Factors Biology Biochemistry Polymerase Chain Reaction chemistry.chemical_compound Endometrium Structural Biology Internal medicine Complementary DNA Genetics medicine Humans Amino Acid Sequence Gene Fallopian Tubes chemistry.chemical_classification Antiserum Expressed Sequence Tags Platelet-Derived Growth Factor Messenger RNA Lymphokines Base Sequence Sequence Homology Amino Acid Vascular Endothelial Growth Factors Growth factor Molecular biology Amino acid medicine.anatomical_structure Endocrinology chemistry Female |
| Zdroj: | Biochimica et biophysica acta. 1492(1) |
| ISSN: | 0006-3002 |
| Popis: | We isolated the cDNA of a novel platelet-derived growth factor-like gene from human endometrium. The gene was named fallotein; it was 3007 bases in length, and encoded a protein of 345 amino acids. Antiserum against the fallotein protein can recognize a specific protein in the fallopian tube, with a molecular size in accordance with the anticipated size of fallotein. Fallotein mRNA is expressed in two molecular sizes, 3.8 and 2.9 kb, with the former being more abundant. High expression of the gene was found in the prostate, testis, and uterus. A weaker expression signal was found in the spleen, thymus, and small intestine, but expression of fallotein in the colon and peripheral blood leukocytes was negligible. |
| Databáze: | OpenAIRE |
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