Antinociceptive and anti-inflammatory activity of hydroalcoholic extracts and fractions from Erythrina mulungu
| Autor: | Anne P. R. Porfírio, Magna Suzana Alexandre-Moreira, João Xavier de Araújo-Júnior, Antônio Euzébio Goulart Santana, Bárbara Viviana de Oliveira Santos, Mariana S. G. de Oliveira, Anansa Bezerra de Aquino, Mariana da Silva Santos, Daniel L. da Silva, Pedro G. V. Aquino |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
biology
medicine.drug_class Zymosan Ethyl acetate lcsh:RS1-441 Opioid system Pharmacology biology.organism_classification Anti-inflammatory antinociceptive lcsh:Pharmacy and materia medica Peritoneal cavity chemistry.chemical_compound medicine.anatomical_structure Nociception Erythrina mulungu chemistry medicine General Pharmacology Toxicology and Pharmaceutics Hot plate test Antiimflammatory |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 22, Iss 1, Pp 157-161 (2011) Revista Brasileira de Farmacognosia, Volume: 22, Issue: 1, Pages: 157-161, Published: 21 NOV 2011 Revista Brasileira de Farmacognosia, Vol 22, Iss 1, Pp 157-161 (2012) Revista Brasileira de Farmacognosia v.22 n.1 2012 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| Popis: | Erythrina mulungu Mart. ex Benth., Fabaceae, popularly known as mulungu, is used for the treatment of insomnia and disorders of the central nervous system. This study examined the antinociceptive effects of the hydroalcoholic extracts (HAE), the ethyl acetate and chloroformic fractions from E. mulungu in four experimental models of nociception using laboratory mice. The extracts and fractions were administered orally to mice at doses of 100 mg/kg. Inhibition of abdominal contractions were observed for all the extracts and fractions tested, as compared to controls. All extracts and fractions from E. mulungu reduced the nociception activity produced by formalin in the 2nd phase. In the hot plate test no significant effect was observed for any extract or fraction. In the peritonitis test induced by Zymosan, all of the tested extracts and the chloroformic fraction, except for the ethyl acetate phase, reduced cell migration of the peritoneal cavity. We concluded that E. mulungu shows antinociceptive effects, which are independent of the opioid system. |
| Databáze: | OpenAIRE |
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