Regional impairment of cortical and deep gray matter perfusion in preterm neonates with low-grade germinal matrix-intraventricular hemorrhage: an ASL study
| Autor: | Paolo Massirio, Luca A Ramenghi, Mariasavina Severino, Alessandro Parodi, Domenico Tortora, Andrea Rossi, Francesco Maria Lo Russo |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Caudate nucleus Perfusion scanning Germinal matrix Infant Premature Diseases Cerebral blood flow Germinal matrix hemorrhage Magnetic resonance Neonate Perfusion Cerebral Ventricles 030218 nuclear medicine & medical imaging 03 medical and health sciences Neonatal Screening 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Gray Matter Cerebral Hemorrhage Retrospective Studies business.industry Infant Newborn Gestational age medicine.disease Magnetic Resonance Imaging Subcortical gray matter Cerebrovascular Circulation Cerebral hemisphere Cardiology Female Spin Labels Neurology (clinical) Cardiology and Cardiovascular Medicine business Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | Neuroradiology. 62:1689-1699 |
| ISSN: | 1432-1920 0028-3940 |
| DOI: | 10.1007/s00234-020-02514-9 |
| Popis: | The long-term impact of low-grade germinal matrix-intraventricular hemorrhage (GMH-IVH) on brain perfusion has not been fully investigated. We aimed to compare cortical and deep gray matter (GM) cerebral blood flow (CBF) obtained with pseudo-continuous arterial spin labeling (pCASL), among preterm neonates with and without low-grade GMH-IVH and full-term controls. 3T-pCASL examinations of 9 healthy full-term neonates (mean gestational age 38.5 weeks, range 38–39) and 28 preterm neonates studied at term-equivalent age were analyzed. Eighteen preterm neonates presented normal brain MRI (mean gestational age 30.50 weeks, range 29–31) and 10 low-grade GMH-IVH according to Volpe’s grading system (mean gestational age 32 weeks, range 28–34). A ROI-based mean CBF quantification was performed in 5 cortical (frontal, parietal, temporal, insula, occipital), and 4 subcortical GM regions (caudate, putamen, pallidum, thalamus) for each cerebral hemisphere. CBF differences were explored using a nonparametric analysis of covariance. Low-grade GMH-IVH hemispheres showed consistently lower CBF in all GM regions when compared with healthy preterm neonates, after controlling the confounding effect of gestational age, postmenstrual age, and birth weight P |
| Databáze: | OpenAIRE |
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