Expression of α-gustducin in the circumvallate papillae of taste buds of diabetic rats
| Autor: | Li-ou Han, Xiao-Min Liu, Xiao-hong Feng, Li-Hong Zhou, Guo-dong Liu |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Taste Histology Gene Expression Umami Biology Diabetes Mellitus Experimental Taste Disorders TAS1R3 stomatognathic system TAS1R2 Taste receptor Internal medicine medicine Animals RNA Messenger Transducin Rats Wistar Lingual papilla Reverse Transcriptase Polymerase Chain Reaction food and beverages Cell Biology General Medicine Taste Buds Immunohistochemistry Rats TAS2R38 Endocrinology Taste disorder |
| Zdroj: | Acta Histochemica. 111:145-149 |
| ISSN: | 0065-1281 |
| DOI: | 10.1016/j.acthis.2008.05.007 |
| Popis: | Taste impairment is a complication of Diabetes mellitus and some studies have shown this taste disorder in diabetes. Diabetes can decrease the ability of individuals to detect and recognize sweet, salty and bitter tastes. alpha-Gustducin is a transducin-like G-protein selectively expressed in 20 - 30% of taste receptor cells, which has been shown to be involved in bitter, sweet and umami taste responses. The present study was performed to explore the protein and mRNA expression of alpha-gustducin in the taste buds of diabetic and control rat circumvallate papillae. Our results showed that the positive expression of alpha-gustducin in diabetic rat taste bud cells is higher than that in normal controls as shown by both immunohistochemistry and RT-PCR. There may be some variant of bitter, sweet or umami taste transduction during diabetes and that taste transduction variant may be one cause of diabetic taste impairment. |
| Databáze: | OpenAIRE |
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