New Therapeutic Tools to Shape Monocyte Functional Phenotypes in Leishmaniasis
| Autor: | Marcela F. Lopes, Natália S Vellozo, Thaís S Rigoni |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Mini Review Immunology Adaptive Immunity Mice 03 medical and health sciences 0302 clinical medicine nitric oxide Immunity medicine Animals Humans Immunology and Allergy Macrophage Leishmania major ATRA Efferocytosis Leishmaniasis Leishmania Innate immune system biology Macrophages Monocyte RANKL RC581-607 Acquired immune system biology.organism_classification Immunity Innate 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunologic diseases. Allergy monocytes M1 and M2 macrophages |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.704429 |
| Popis: | In the innate immunity toLeishmaniainfection tissue-resident macrophages and inflammatory monocytes accumulate host-cell, effector, and efferocytosis functions. In addition, neutrophils, as host, effector, and apoptotic cells, as well as tissue-resident and monocyte-derived dendritic cells (DCs) imprint innate and adaptive immunity toLeishmaniaparasites. Macrophages develop phenotypes ranging from antimicrobial M1 to parasite-permissive M2, depending on mouse strain,Leishmaniaspecies, and T-cell cytokines. The Th1 (IFN-γ) and Th2 (IL-4) cytokines, which induce classically-activated (M1) or alternatively-activated (M2) macrophages, underlie resistance versus susceptibility to leishmaniasis. While macrophage phenotypes have been well discussed, new developments addressed the monocyte functional phenotypes inLeishmaniainfection. Here, we will emphasize the role of inflammatory monocytes to access how potential host-directed therapies for leishmaniasis, such as all-trans-retinoic acid (ATRA) and the ligand of Receptor Activator of Nuclear Factor-Kappa B (RANKL) might modulate immunity toLeishmaniainfection, by directly targeting monocytes to develop M1 or M2 phenotypes. |
| Databáze: | OpenAIRE |
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