Abrupt awakening phenomenon associated with gamma-hydroxybutyrate use: A case series

Autor:	Peter De Paepe, Diederik Van Sassenbroeck, Alain Verstraete, Frans M. Belpaire, Paul Calle, Nikolaas De Neve, Walter Buylaert
Rok vydání:	2007
Předmět:	Adult Male medicine.medical_specialty Adolescent Neurological disorder Toxicology Belgium Seizures medicine Humans Glasgow Coma Scale Coma Wakefulness Series (stratigraphy) Illicit Drugs business.industry Gamma hydroxybutyrate General Medicine medicine.disease Surgery Sudden awakening Pharmacodynamics Anesthesia Time course Female Drug Overdose medicine.symptom Sodium Oxybate business
Zdroj:	Clinical Toxicology. 45:533-538
ISSN:	1556-9519 1556-3650
DOI:	10.1080/15563650701365818
Popis:	Case reports mention a sudden awakening from GHB-associated coma but do not specify its time course. The aim of the present case series was to investigate the time course of the awakening from GHB intoxication and the relationship to plasma concentrations of GHB and the presence of other drugs. Unconscious (GCSor=8) participants at six large rave parties who were treated at medical stations were included. Serial blood samples were taken every 10 to 30 minutes for toxicological analysis. At the same time-points, the depth of coma was scored with the Glasgow Coma Score (GCS). Fifteen out of 21 unconscious patients proved to be positive for GHB. Fourteen of these had ingested one or more other drugs. The median GHB plasma concentration upon arrival in the medical station was 212 microg/ml (range 112 to 430 microg/ml). In 10 patients the GCS was scored more than twice, allowing study of the time course. The GCS of these patients remainedor=8 for a median time of 90 minutes (range 30 to 105 minutes). The duration of the transition between GCS ofor=8 andor=12 was 30 minutes (range 10 to 50 minutes). A subgroup of five patients had a GCS of 3 upon arrival and remained at 3 for a median time of 60 minutes (range 30 to 110 minutes), while the median time for the transition between the last point with GCS 3 and the first with GCS 15 was 30 minutes (range 20 to 60 minutes). This case series illustrates that patients with GHB intoxications remain in a deep coma for a relatively long period of time, after which they awaken over about 30 minutes. This awakening is accompanied by a small change in GHB concentrations. A confounding factor in these observations is co-ingested illicit drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d88e3b2327b0248aaad8cba9d152826 https://doi.org/10.1080/15563650701365818 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.