Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies

Autor: Eduardo Fournier, Erika Cheung, Silvia Monge, Kevin L. Delucchi, Luis Diego Herrera, Viviana A. Peskin, Monica Berrocal, Anna E. Ordóñez, Carol A. Mathews, R. Scott Mackin, Judith A. Badner, James J. McGough, Denise A. Chavira
Rok vydání: 2015
Předmět:
Male
Inheritance Patterns
CBCL
Neuropsychological Tests
heritability
Cognition
Models
2.1 Biological and endogenous factors
Aetiology
Child Behavior Checklist
Child
Genetics (clinical)
Pediatric
Principal Component Analysis
Neuropsychology
Statistical
Pedigree
Psychiatry and Mental health
Phenotype
Mental Health
Female
Psychology
Factor Analysis
Clinical psychology
Adult
Costa Rica
Adolescent
Clinical Sciences
Basic Behavioral and Social Science
Article
cognitive
Cellular and Molecular Neuroscience
Young Adult
pedigrees
Genetic
Clinical Research
mental disorders
Behavioral and Social Science
medicine
Genetics
Attention deficit hyperactivity disorder
Humans
ADHD
Genetic Predisposition to Disease
Behavior
Models
Genetic
Genetic heterogeneity
Siblings
Neurosciences
Heritability
medicine.disease
endophenotypes
Attention Deficit Hyperactivity Disorder (ADHD)
Brain Disorders
Attention Deficit Disorder with Hyperactivity
Endophenotype
Factor Analysis
Statistical
Neurocognitive
Zdroj: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, vol 168B, iss 4
Peskin, VA; Ordóñez, A; Mackin, RS; Delucchi, K; Monge, S; Mcgough, JJ; et al.(2015). Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 168(4), 247-257. doi: 10.1002/ajmg.b.32305. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5710v578
Popis: © 2015 Wiley Periodicals, Inc. Attention deficit hyperactivity disorder (ADHD) is associated with substantial functional impairment in children and in adults. Many individuals with ADHD have clear neurocognitive deficits, including problems with visual attention, processing speed, and set shifting. ADHD is etiologically complex, and although genetic factors play a role in its development, much of the genetic contribution to ADHD remains unidentified. We conducted clinical and neuropsychological assessments of 294 individuals (269 with ADHD) from 163 families (48 multigenerational families created using genealogical reconstruction, 78 affected sib pair families, and 37 trios) from the Central Valley of Costa Rica (CVCR). We used principal components analysis (PCA) to group neurocognitive and behavioral variables using the subscales of the Child Behavior Checklist (CBCL) and 15 neuropsychological measures, and created quantitative traits for heritability analyses. We identified seven cognitive and two behavioral domains. Individuals with ADHD were significantly more impaired than their unaffected siblings on most behavioral and cognitive domains. The verbal IQ domain had the highest heritability (92%), followed by auditory attention (87%), visual processing speed and problem solving (85%), and externalizing symptoms (81%). The quantitative traits identified here have high heritabilities, similar to the reported heritability of ADHD (70-90%), and may represent appropriate alternative phenotypes for genetic studies. The use of multigenerational families from a genetically isolated population may facilitate the identification of ADHD risk genes in the face of phenotypic and genetic heterogeneity.
Databáze: OpenAIRE
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