Toxicity of particles emitted by fireworks
| Autor: | Lung Chi Chen, James Ross, Karen Galdanes, Steven N. Chillrud, Christina Hickey, Terry Gordon, Christopher Gordon, Lital Yinon, Martin Blaustein, Lori Horton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis Air pollution lcsh:Industrial hygiene. Industrial welfare Fireworks Inflammation 010501 environmental sciences Pharmacology Toxicology 01 natural sciences Cell Line 03 medical and health sciences Mice 0302 clinical medicine In vitro In vivo lcsh:RA1190-1270 medicine Animals 030212 general & internal medicine Particle Size Cytotoxicity Lung 0105 earth and related environmental sciences lcsh:Toxicology. Poisons chemistry.chemical_classification Reactive oxygen species Air Pollutants medicine.diagnostic_test Chemistry Research Inhaled metals Epithelial Cells General Medicine Pneumonia Bronchoalveolar lavage Particles Metals Toxicity Particulate Matter Particle size medicine.symptom Bronchoalveolar Lavage Fluid lcsh:HD7260-7780.8 |
| Zdroj: | Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-11 (2020) Particle and Fibre Toxicology |
| ISSN: | 1743-8977 |
| Popis: | Background Particle matter (PM) has been associated with increased morbidity and mortality rates across the world. This study was designed to test the hypotheses that pyrotechnic firework displays introduce significant amounts of toxic metals into the atmosphere and are hazardous to human health. Size-selective emissions from 10 different fireworks displays were collected during particle generation in a dynamic, stainless steel chamber and tested for toxicity in cells. A subset of 2 particle types were tested in vivo in mice. At doses that did not produce cytotoxicity in an LDH assay, in vitro reactive oxygen species (ROS) formation was measured in bronchial epithelial airway (BEAS-2B) and human pulmonary microvascular endothelial (HPMEC-ST1.6R) cell lines treated with size-fractionated particles from the emissions of fireworks. Results Significant increases in ROS, in both cell types, were dependent upon the type of firework but not particle size. The in vitro ROS activity was correlated with lung inflammation produced in groups of mice treated by oropharyngeal aspiration with 0, 50, or 100 μg fireworks PM10/mouse. Trace metal analyses of the PM10 samples showed significant differences in metal content among fireworks type. Interestingly, the PM10 sample for the fireworks type producing the greatest in vitro ROS response in BEAS-2B cells contained ~ 40,000 and ~ 12,000 ppm of lead and copper, respectively. This sample also produced the greatest inflammatory response (i.e., increased neutrophils in bronchoalveolar lavage fluid) in mice. Conclusions These findings demonstrate that pyrotechnic display particles can produce adverse effects in mammalian cells and lungs, thus suggesting that further research is needed to expand our understanding of the contribution of metal content to the adverse health effects of fireworks particles. This information will lead to the manufacture of safer fireworks. |
| Databáze: | OpenAIRE |
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