The insulin action-fiber type relationship in humans is muscle group specific
| Autor: | M. D. Weidner, Matthew S. Hickey, Joseph A. Houmard, Donghai Zheng, G. L. Tyndall, K. E. Gavigan |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Muscle Fibers Skeletal Adipose tissue Citrate (si)-Synthase In vivo Physiology (medical) Internal medicine medicine Humans Citrate synthase Muscle Skeletal Pancreatic hormone Anthropometry biology Fiber type Insulin Skeletal muscle Metabolism Endocrinology medicine.anatomical_structure biology.protein Regression Analysis Insulin Resistance |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 269:E150-E154 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1995.269.1.e150 |
| Popis: | The purpose of the present investigation was to determine the relationship between skeletal muscle characteristics, adiposity, and in vivo insulin action. Percutaneous muscle biopsies of the vastus lateralis (VL) and gastrocnemius (G) muscles were obtained from twenty-two sedentary male subjects. Insulin sensitivity (SI) and glucose effectiveness (SG) were determined from minimal model analysis, and indexes of regional and overall adiposity were obtained. SI was positively related to the citrate synthase activity from the VL (r = 0.50, P < 0.01) but unrelated to the citrate synthase activity from the G (r = 0.28). Similarly, SI was inversely related to the percentage of type IIb fibers in the VL (r = -0.47, P < 0.01) but unrelated to the percentage of type IIb fibers in the G (r = 0.06). SG was unrelated to fiber type, oxidative capacity, or adiposity. These data suggest that oxidative capacity and other characteristics related to VL skeletal muscle fiber type are determinants of in vivo insulin action but that this relationship cannot be extended to all muscle groups. Finally, neither skeletal muscle characteristics nor adiposity appears to be a determinant of SG in sedentary males. |
| Databáze: | OpenAIRE |
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