Transmission of trained immunity and heterologous resistance to infections across generations

Autor: Gilles Gasparoni, Andreas Schlitzer, Branko Cirovic, Joachim L. Schultze, Didier Le Roy, Kristian Händler, Evangelos J. Giamarellos-Bourboulis, Jorge Domínguez-Andrés, Jörn Walter, Leo A. B. Joosten, Marc Beyer, Jos W. M. van der Meer, Kathrin Kattler, Heidi Theis, Natalie Katzmarski, Mihai G. Netea, Eleonora Ciarlo, Georgios Renieris, Konstantin Lepikhov, Thierry Roger
Rok vydání: 2021
Předmět:
Male
Heredity
Transcription
Genetic
genetics [Escherichia coli Infections]
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
immunology [Escherichia coli]
Epigenesis
Genetic
microbiology [Listeriosis]
Candida albicans
Immunology and Allergy
Listeriosis
Myeloid Cells
genetics [Listeriosis]
Escherichia coli Infections
Cells
Cultured
immunology [Escherichia coli Infections]
metabolism [Spermatozoa]
biology
immunology [Listeriosis]
Effector
Candidiasis
immunology [Listeria monocytogenes]
Spermatozoa
pathogenicity [Candida albicans]
metabolism [Escherichia coli Infections]
immunology [Candidiasis]
pathogenicity [Escherichia coli]
immunology [Candida albicans]
DNA methylation
Host-Pathogen Interactions
Transgene
genetics [Candidiasis]
Immunology
Heterologous
Mice
Transgenic
metabolism [Myeloid Cells]
Immune system
Immunity
Escherichia coli
Animals
Epigenetics
ddc:610
metabolism [Listeriosis]
pathogenicity [Listeria monocytogenes]
microbiology [Escherichia coli Infections]
microbiology [Candidiasis]
DNA Methylation
biology.organism_classification
Listeria monocytogenes
Immunity
Innate
genetics [Immunity
Innate]
Disease Models
Animal
microbiology [Myeloid Cells]
metabolism [Candidiasis]
immunology [Spermatozoa]
immunology [Myeloid Cells]
Zdroj: Nature Immunology, 22, 1382-1390
Nature immunology 22(11), 1382-1390 (2021). doi:10.1038/s41590-021-01052-7
Nature Immunology, 22, 11, pp. 1382-1390
Nat Immunol.
ISSN: 1529-2908
DOI: 10.1038/s41590-021-01052-7
Popis: Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous Escherichia coli and Listeria monocytogenes infections. Sperm DNA of parental male mice intravenously infected with the fungus C. albicans showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections. Transgenerational transmission of acquired immunological traits has been demonstrated in invertebrates and plants but not mammals. Katzmarski et al. demonstrate that trained immunity that protects against heterologous infections can be transmitted to F2 offspring.
Databáze: OpenAIRE
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