Risk of Infectious Complications After Simultaneous Gastrointestinal and Liver Resections for Neuroendocrine Tumor Metastases
| Autor: | Luis F. Acosta, Pedro Eman, Roberto Gedaly, Eduardo Chacon, Adam Dugan, Daniel L. Davenport |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Liver resections Neuroendocrine tumors 03 medical and health sciences Postoperative Complications 0302 clinical medicine Surgery procedure medicine Humans Digestive System Surgical Procedures Aged Gastrointestinal Neoplasms Retrospective Studies Colorectal resection business.industry Liver Neoplasms Middle Aged Pancreaticoduodenectomy medicine.disease United States Surgery Neuroendocrine Tumors Increased risk 030220 oncology & carcinogenesis Concomitant Female 030211 gastroenterology & hepatology Hepatectomy business |
| Zdroj: | Journal of Surgical Research. 235:244-249 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/j.jss.2018.10.009 |
| Popis: | Neuroendocrine tumors (NETs) are a relatively rare category of cancers that arise in the gastrointestinal (GI) tract and other organs. Extended hepatectomies including resection of multiple organs are often necessary to achieve negative margins.We performed a review of patients undergoing liver resection for NET liver metastases from 2005 to 2015 using National Surgical Quality Improvement Program. We compared patients undergoing hepatectomy alone (HA) versus hepatectomy and a concomitant GI surgery procedure (colorectal, small bowel, and pancreatic) to evaluate postoperative infectious complications.During the study period, 354 patients underwent liver resection for metastatic NET. Hepatectomy alone was performed in 98 patients, and concomitant GI surgery was performed in 256 patients, including 83 colorectal resections (HCCR), 68 small bowel resections, 75 distal pancreatectomies, and 35 pancreaticoduodenectomies (HCPD). Infectious complications were more likely to occur in those undergoing HCPD (60%, P 0.001), and HCCR (32.5%, P 0.05) than in those undergoing HA (16.3%). Patients undergoing HCPD and HCCR had a 7.69-fold and 2.52-fold increased risk of infectious complication, respectively, compared with HA after adjustment for other infection risk factors.Neuroendocrine liver metastases requiring liver resection with concomitant colorectal resection or pancreaticoduodenectomy are at significantly increased risk of developing infectious complications. |
| Databáze: | OpenAIRE |
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