Effects of Subdural Monopolar Cortical Stimulation Paired With Rehabilitative Training on Behavioral and Neurophysiological Recovery After Cortical Ischemic Stroke in Adult Squirrel Monkeys
| Autor: | Erik J. Plautz, Shawn B. Frost, Ann M. Stowe, Scott D. Bury, Scott Barbay, Ines Eisner-Janowicz, Numa Dancause, Michael D. Taylor, Randolph J. Nudo, Elena V. Zoubina |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Electric Stimulation Therapy Article Brain Ischemia Premotor cortex Brain ischemia 03 medical and health sciences 0302 clinical medicine biology.animal Neuroplasticity medicine Animals Primate Stroke Saimiri Neuronal Plasticity biology Behavior Animal Motor Cortex Stroke Rehabilitation General Medicine Recovery of Function medicine.disease Surgery Disease Models Animal 030104 developmental biology medicine.anatomical_structure Anesthesia Female Primary motor cortex Forelimb Psychology 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Neurorehabilitation and neural repair. 30(2) |
| ISSN: | 1552-6844 |
| Popis: | Background. Cortical stimulation (CS) combined with rehabilitative training (RT) has proven effective for enhancing poststroke functional recovery in rats, but human clinical trials have had mixed outcomes. Objective. To assess the efficacy of CS/RT versus RT in a nonhuman primate model of cortical ischemic stroke. Methods. Squirrel monkeys learned a pellet retrieval task, then received an infarct to the distal forelimb (DFL) representation of primary motor cortex. A subdural monopolar electrode was implanted over the spared DFL representation in dorsal premotor cortex (PMD). Seven weeks postinfarct, monkeys underwent 4 to 6 weeks of RT (n = 8) or CS/RT (n = 7; 100 Hz, cathodal current) therapy. Behavioral performance was assessed before and after infarct, prior to therapy, and 1 and 12 weeks posttherapy (follow-up). The primary outcome measure was motor performance at 1 week posttherapy. Secondary outcomes included follow-up performance at 12 weeks and treatment-related changes in neurophysiological maps of spared DFL representations. Results. While postinfarct performance deficits were found in all monkeys, both groups demonstrated similar recovery profiles, with no difference in motor recovery between the RT and CS/RT groups. Posttherapy, PMD DFL area was significantly expanded in the RT group but not the CS/RT group. A significant relationship was found between motor recovery and DFL expansion in premotor cortex. Conclusions. Results suggest that the specific parameters utilized here were not optimal for promoting behavioral recovery in nonhuman primates. Though CS/RT has consistently shown efficacy in rat stroke models, the present finding has cautionary implications for translation of CS/RT therapy to clinical populations. |
| Databáze: | OpenAIRE |
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