Significance of anti-pre-S antibodies in patients with fulminant hepatic failure
| Autor: | Gandhi Bm, Yogendra Kumar Joshi, Tandon Bn, Subrat K. Acharya, Mohammad Irshad |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
HBsAg
medicine.medical_specialty Hepatitis B Surface Antigens biology business.industry Gastroenterology virus diseases Hepatology Hepatitis B digestive system diseases Fulminant hepatic failure Viral Envelope Proteins Hepatic Encephalopathy Internal medicine Immunology medicine biology.protein Humans In patient Hepatitis B Antibodies Protein Precursors Antibody Fulminant hepatitis business |
| Zdroj: | Gastroenterologia Japonica. 25:499-502 |
| ISSN: | 0435-1339 |
| DOI: | 10.1007/bf02779341 |
| Popis: | Anti-pre-S antibody was tested in 38 sera from patients with fulminant hepatitis (positive for HBsAg and/or IgM anti-HBc) using a specific solid phase enzyme linked immunosorbent assay (ELISA). Anti-pre-S activity was detected in 50 percent sera samples positive for HBsAg but negative for IgM anti-HBc. There were 12.5% sera positive for both HBsAg as well as IgM anti-HBc and 75% sera negative for HBsAg but positive for IgM anti-HBc. The prevalence of HBV-specific DNA-polymerase activity was high in all the three groups whereas anti-HBs positivity was low. Anti-pre-S activity was observed both in the presence as well as in the absence of DNA-polymerase activity. High-anti-pre-S level in fulminant hepatitis B patients was assumed to be implicated in the fast clearance of HBsAg from circulation. |
| Databáze: | OpenAIRE |
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