Interrelationships of loss of vascular competence, ATP depletion, and decreased tissue compressibility in developing myocardial infarcts
| Autor: | R.N. Seelye, V.J. Webster, S.M. Humphrey, John B. Gavin |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Myocardial ischemia Myocardial Infarction Ischemia Coronary Disease Biochemistry chemistry.chemical_compound Adenosine Triphosphate Dogs Left coronary artery Atp depletion Internal medicine medicine.artery Animals Medicine Circumflex Fluorescein business.industry Papillary Muscles medicine.disease chemistry Anesthesia Cardiology Vascular Resistance Ligation business Perfusion |
| Zdroj: | Biochemical Medicine. 24:6-15 |
| ISSN: | 0006-2944 |
| DOI: | 10.1016/0006-2944(80)90080-0 |
| Popis: | Varying periods of myocardial ischemia were induced in dogs by ligation of the circumflex branch of the left coronary artery. ATP decreased with increasing duration of ischemia and was less than 20% of the control area by 45 min. In one group, iodoacetate was injected into the ischemic area. Comparisons between untreated and treated groups showed an expected acceleration of tissue ATP loss in the iodoacetate-injected group. This accelerated loss was accompanied by a corresponding acceleration in loss of vascular competence (as judged by fluorescein perfusion of the ischemic area) and a variable but usually accelerated reduction in tissue compressibility. This investigation has demonstrated that the development of the no-flow phenomenon in early myocardial infarcts is critically related to depletion of ATP. It commences when ATP falls below half the initial level and is fully developed when it has fallen to 20% of normal. |
| Databáze: | OpenAIRE |
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