The effect of human leukocyte Antigens-DRB1 alleles on development of different tuberculosis forms in children
| Autor: | Piotr Yablonskiy, Irina F. Dovgalyuk, Ludmila N. Bubnova, Yulia Ovchinnikova, Andrey Berkos, Anna Starshinova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Microbiology (medical) Tuberculosis Adolescent lcsh:QR1-502 immunogenetic diagnosis Disease Human leukocyte antigen lcsh:Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans Genetic Predisposition to Disease Allele Child Tuberculosis Pulmonary Gene Genotyping Children Alleles Polymorphism Genetic Lung business.industry Infant Mycobacterium tuberculosis medicine.disease HLA alleles Infectious Diseases medicine.anatomical_structure 030228 respiratory system genotyping tuberculosis Child Preschool Immunology Female business HLA-DRB1 Chains |
| Zdroj: | International Journal of Mycobacteriology, Vol 7, Iss 2, Pp 117-121 (2018) |
| ISSN: | 2212-5531 |
| Popis: | Background: Nowadays, there is no doubt that the development of infectious process is determined not only by individual features of a human, but also by features of infection agent. It is commonly known that ability to form an adequate immune response is based on immunogenetic peculiarities of macroorganism. Methods: The immunogenetic study was performed in 228 children from 1 to 15 years old with different manifestations of tuberculosis (TB). Control group was consisted of 446 adult healthy donors-residents of the Northwestern region of Russia. Human leukocyte antigens (HLA)-DRB1* allelic genes were assessed in all individuals. Results: HLA-DRB1 alleles *01, *03, *11, *13, *07, and *15 were observed significantly rare in children with TB in comparison with healthy donors that may indicate their protective role in the development of the disease. It was also noticed that DRB1 *07 and *15 alleles were observed significantly rare in children with lung TB in comparison with other forms of disease that allows to assume a protective function of these alleles for lung TB with no influence on development of generalized TB. This assumption requires further researches. Conclusion: As a result of the study, statistically significant differences in the distribution of HLA-DRB1* alleles in children with TB in comparison with a control group for *01, *03, *11, *13, *07, *15, and *16 alleles were found. It may indicate their protective role in the development of TB. DRB1 *07 and *15 alleles were observed significantly rare in children with single TB than in children with generalized TB and healthy controls. |
| Databáze: | OpenAIRE |
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