Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Autor: Muzna Sadia, Waqar Ahmed, Agata Sośnicka, Mohamed Albed Alhnan, Basel Arafat, Antonios Kelarakis, Abdullah Isreb
Rok vydání: 2016
Předmět:
Calcium Phosphates
Captopril
F162
Drug Compounding/methods
F200
Pharmaceutical Science
3D printing
Lactose
02 engineering and technology
H700
030226 pharmacology & pharmacy
Dosage form
Theophylline/chemistry
chemistry.chemical_compound
0302 clinical medicine
Mesalamine
chemistry.chemical_classification
Prednisolone/chemistry
Polymer
021001 nanoscience & nanotechnology
Microcrystalline cellulose
Tablets/chemistry
Talc
Polymethacrylic Acids/chemistry
Printing
Three-Dimensional
Extrusion
0210 nano-technology
Tablets
medicine.drug
Talc/chemistry
Fabrication
Materials science
Drug Compounding
Prednisolone
Fused filament fabrication
Excipients
03 medical and health sciences
Polymethacrylic Acids
Theophylline
medicine
Humans
Cellulose
Cellulose/chemistry
F151
business.industry
H812
Drug Liberation
chemistry
Chemical engineering
Lactose/chemistry
Calcium Phosphates/chemistry
Captopril/chemistry
Mesalamine/chemistry
business
Excipients/chemistry
Zdroj: Sadia, M, Sośnicka, A, Arafat, B, Isreb, A, Ahmed, W, Kelarakis, A & Alhnan, M A 2016, ' Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets ', INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 513, no. 1-2, pp. 659-668 . https://doi.org/10.1016/j.ijpharm.2016.09.050
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2016.09.050
Popis: This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with several model drugs. It investigates the addition of non-melting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of (i) the nature of filler, (ii) compatibility with the gears of the 3D printer and iii) polymer: filler ratio on the 3D printing process. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135°C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet. A specially developed universal filament based on pharmaceutically approved methacrylic polymer (Eudragit EPO) and thermally stable filler, TCP (tribasic calcium phosphate) was optimised. Four model drugs with different physicochemical properties were included into ready-to-use mechanically stable tablets with immediate release properties. Following the two thermal processes (hot melt extrusion (HME) and fused deposition modelling (FDM) 3D printing), drug contents were 94.22%, 88.53%, 96.51% and 93.04% for 5-ASA, captopril, theophylline and prednisolone respectively. XRPD indicated that a fraction of 5-ASA, theophylline and prednisolone remained crystalline whilst captopril was in amorphous form. By combining the advantages of thermally stable pharmaceutically approved polymers and fillers, this unique approach provides a low cost production method for on demand manufacturing of individualised dosage forms.
Databáze: OpenAIRE
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