Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
| Autor: | Mairene Coto-Llerena, Nicole von Burg, Edit Horvath, Daniela Finke, Daniel Staehli, Christoph Mueller, Gleb Turchinovich, Mercedes Gomez de Agüero, Tobias Eichlisberger, Frank M. Lehmann, Mohamed Bentires-Alj, Robert Ivanek, Claudia Teufel, Michaela Prchal-Murphy, Veronika Sexl, Annick Peter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Transcription Genetic T-Lymphocytes Cell General Physics and Astronomy mTORC1 Lymphocyte Activation Interleukin-23 Mice 0302 clinical medicine Intestinal mucosa Interferon Lymphocytes Phosphorylation Promoter Regions Genetic skin and connective tissue diseases lcsh:Science 610 Medicine & health Antigen Presentation Principal Component Analysis Multidisciplinary Microbiota Innate lymphoid cell Cell Polarity Nuclear Proteins Cell biology medicine.anatomical_structure Phenotype Mucosal immunology medicine.drug STAT3 Transcription Factor T cell Science Antigen presentation T cells Antigen-Presenting Cells Down-Regulation Innate lymphoid cells Biology Mechanistic Target of Rapamycin Complex 1 digestive system General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Interferon-gamma Antigen SDG 3 - Good Health and Well-being Antigens CD medicine Animals RNA Messenger Interleukins Histocompatibility Antigens Class II General Chemistry Immunity Innate body regions 030104 developmental biology Trans-Activators 570 Life sciences biology lcsh:Q Spleen 030215 immunology |
| Zdroj: | Lehmann, Frank Michael; von Burg, Nicole; Ivanek, Robert; Teufel, Claudia; Horvath, Edit; Peter, Annick; Turchinovich, Gleb; Staehli, Daniel; Eichlisberger, Tobias; Gomez de Agüero, Mercedes; Coto-Llerena, Mairene; Prchal-Murphy, Michaela; Sexl, Veronika; Bentires-Alj, Mohamed; Mueller, Christoph; Finke, Daniela (2020). Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation. Nature communications, 11(1), p. 1794. Nature Publishing Group 10.1038/s41467-020-15612-2 Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) Lehmann, F M, von Burg, N, Ivanek, R, Teufel, C, Horvath, E, Peter, A, Turchinovich, G, Staehli, D, Eichlisberger, T, Gomez de Agüero, M, Coto-Llerena, M, Prchal-Murphy, M, Sexl, V, Bentires-Alj, M, Mueller, C & Finke, D 2020, ' Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation ', Nature Communications, vol. 11, no. 1, 1794 . https://doi.org/10.1038/s41467-020-15612-2 Nature Communications |
| DOI: | 10.7892/boris.145796 |
| Popis: | Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in the spleen, they fail to induce CD4+ T cell proliferation in the gut. The signals regulating ILC3-T cell responses remain unknown. Here, we show that transcripts associated with MHC II antigen presentation are down-modulated in intestinal natural cytotoxicity receptor (NCR)− ILC3s. Further data implicate microbiota-induced IL-23 as a crucial signal for reversible silencing of MHC II in ILC3s, thereby reducing the capacity of ILC3s to present antigen to T cells in the intestinal mucosa. Moreover, IL-23-mediated MHC II suppression is dependent on mTORC1 and STAT3 phosphorylation in NCR− ILC3s. By contrast, splenic interferon-γ induces MHC II expression and CD4+ T cell stimulation by NCR− ILC3s. Our results thus identify biological circuits for tissue-specific regulation of ILC3-dependent T cell responses. These pathways may have implications for inducing or silencing T cell responses in human diseases. Group 3 innate lymphoid cells (ILC3s) promote T cell activation in the spleen but suppress it in the gut. Here, the authors show that this distinct regulation is mediated by gut microbiota-induced IL-23 and IFN-γ, respectively, and, along with the article by Rao et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation. |
| Databáze: | OpenAIRE |
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