Coronary blood flow assessment with xenon and rubidium
| Autor: | Harold T. Tillmanns, Richard J. Bing, Otmar M. Pachinger |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Xenon chemistry.chemical_element Rubidium Coronary artery disease Coronary circulation Internal medicine Coronary Circulation medicine Humans Radiology Nuclear Medicine and imaging Administration Intranasal Radioisotopes business.industry Blood flow medicine.disease Coronary arteries medicine.anatomical_structure Flow (mathematics) chemistry Injections Intra-Arterial Injections Intravenous Cardiology business Perfusion |
| Zdroj: | Seminars in nuclear medicine. 3(2) |
| ISSN: | 0001-2998 |
| Popis: | A critical review is made of the methods using 133 Xe and 84 Rb for the determination of coronary blood flow. Although coronary blood flow has been measured in man for over 25 yr, an ideal clinically applicable method has not yet been established. The major problem in the xenon method arises when flow is not uniform throughout the heart, as is certainly the case in coronary artery disease. Then the calculation of flow from multiexponential decay curves is problematic. Another difficulty is the dependence of the numerical flow value on the tissue-blood partition coefficient and its possible changes in a diseased state. An additional disadvantage is the requirement of catheterization of the coronary arteries; however, this permits separation of flow through right and left coronary circulation and correlation of flow values directly to anatomic findings obtained on coronary arteriography. The use of 133 Xe also makes the determination of regional flow distribution and measurement of collateral flow possible. The main limitation of the 84 Rb coincidence-counting system lies in its inaccuracy of absolute quantification at high flow rates. Although the determination of nutritional blood flow by the rubidium clearance technique underestimates very high flow rates, it reflects an accurate estimate of directional changes in myocardial blood flow. It is a non-invasive method requiring only venous and arterial punctures. Every area of the myocardium, regardless of the degree of perfusion, contributes to the numerical value of the measurement. |
| Databáze: | OpenAIRE |
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