4-Acetylantroquinonol B Suppresses Tumor Growth and Metastasis of Hepatoma Cells via Blockade of Translation-Dependent Signaling Pathway and VEGF Production
| Autor: | Tur-Fu Huang, Hui-Chin Peng, Chun-Chieh Hsu, Feng-Nien Ko, Shih-Wei Wang, Kung-Tin Lin, Wei-Luen Chang, Ching-Hu Chung, Chien-Hsin Chang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Carcinoma Hepatocellular Down-Regulation Mice Nude Antineoplastic Agents Mice SCID Biology 4-Butyrolactone Cell Movement In vivo Internal medicine medicine Animals Humans Phosphorylation Metatarsal Bones PI3K/AKT/mTOR pathway Cell Proliferation Cyclohexanones Cell growth Kinase TOR Serine-Threonine Kinases Liver Neoplasms Cell migration Hep G2 Cells General Chemistry Cell cycle digestive system diseases Vascular endothelial growth factor A Endocrinology Protein Biosynthesis Antrodia Cancer research General Agricultural and Biological Sciences Antrodia cinnamomea Signal Transduction |
| Zdroj: | Journal of Agricultural and Food Chemistry. 63:208-215 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf504434v |
| Popis: | Hepatocellular carcinoma (HCC) has become one of most common malignancies and a leading cause of cancer mortality worldwide. Previous study has shown that 4-acetylantroquinonol B (4AAQB) isolated from Antrodia cinnamomea (or niu-chang-chih) was observed to inhibit HepG2 cell proliferation via affecting cell cycle. However, the in vivo effects and antimetastatic activity of 4AAQB have not yet been addressed. This study found that 4AAQB inhibited HepG2 and HuH-7 hepatoma cell growth in both in vitro and in vivo models and exhibited pronounced inhibitory effects on HuH-7 tumor growth in xenograft and orthotopic models. 4AAQB efficiently inhibited the phosphorylation of mTOR and its upstream kinases and the downstream effectors and decreased the production of VEGF and activity of Rho GTPases in HuH-7 cells. Furthermore, 4AAQB inhibited in vitro HuH-7 cell migration and in vivo pulmonary metastasis. The results suggested that 4AAQB is a potential candidate for HCC therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|