Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-γ or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection
| Autor: | Fiona Mulcahy, Robert Grealy, J. A. Otegbayo, R. Mac Nicholas, Derek G. Doherty, S. O'Dea, M. J. Conroy, Thomas J. Ryan, M. Taylor, Suzanne Norris |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Hepatitis B virus Adolescent Lymphocyte Gene Expression chemical and pharmacologic phenomena Biology Interleukin 21 Interferon-gamma Young Adult Immune system Antigen Virology medicine Ethnicity Cytotoxic T cell Humans Hepatitis B e Antigens Lymphocyte Count Lymphokine-activated killer cell Hepatology Middle Aged Natural killer T cell Hepatitis B CD56 Antigen Lymphocyte Subsets Interleukin-10 Killer Cells Natural Infectious Diseases medicine.anatomical_structure Case-Control Studies Immunology Asymptomatic Diseases Interleukin 12 Leukocytes Mononuclear Natural Killer T-Cells Female Antigens CD1d |
| Zdroj: | Journal of viral hepatitis. 22(3) |
| ISSN: | 1365-2893 |
| Popis: | Infection with hepatitis B virus (HBV) can result in spontaneous resolution or chronic infection, which can remain asymptomatic or can progress to cirrhosis and/or hepatocellular carcinoma. The host immune response is thought to be a major determinant of the outcome of HBV infection and virus-specific cytotoxic T lymphocytes (CTL) can mediate immunity against the virus and cause liver pathology. Antigen-nonspecific innate lymphocytes may also contribute to HBV infection and liver disease, therefore, we examined the frequencies, phenotypes, cytolytic activities and cytokine profiles of circulating natural killer (NK) cells, CD1d-restricted invariant natural killer T (iNKT) cells and CD56(+) T cells in 102 asymptomatic HBV-infected patients and compared them with those in 66 uninfected control subjects. NK cells expressing low levels of CD56 (CD56(dim)) and CD56(+) T cells were significantly expanded in the circulation of HBV-infected patients compared with control subjects. CD1d expression and iNKT cell frequencies were similar in both groups. Despite these expansions, we did not detect augmented natural or cytokine-induced cytotoxicity in the HBV-infected subjects. All lymphocyte populations studied produced interferon-γ (IFN-γ) significantly more frequently when taken from HBV-infected patients compared with when taken from healthy controls. Additionally, NK cells from the patients more frequently produced interleukin-10. As our HBV-infected cohort consisted of asymptomatic patients with low viral loads, we propose that CD56(dim) NK cells and CD56(+) T cells control HBV infection by noncytolytic mechanisms. |
| Databáze: | OpenAIRE |
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