Pharmaceutical development and clinical effectiveness of a novel gel technology for transdermal drug delivery
| Autor: | Holger Kraus, Dario Norberto R. Carrara, Ingo Alberti, Arnaud Grenier |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Drug
Male Materials science Clinical effectiveness media_common.quotation_subject Pharmaceutical Science Pharmacology medicine.disease_cause Administration Cutaneous Drug Delivery Systems medicine Animals Humans Testosterone Urinary Bladder Neurogenic media_common Transdermal Solvent system Alprazolam Estradiol Progesterone Congeners Hypogonadism Parasympatholytics Permeation Anti-Anxiety Agents Postmenopausal symptoms Drug delivery Mandelic Acids Female Irritation Norethindrone Gels |
| Zdroj: | Expert opinion on drug delivery. 2(5) |
| ISSN: | 1742-5247 |
| Popis: | Transdermal gels are designed to deliver sustained drug amounts, resulting in systemically consistent levels. They represent an improvement compared with transdermal delivery by patches because they offer more dosage flexibility, less irritation potential and a better cosmetic appearance. Advanced Transdermal Delivery (ATD) gel technology was developed in order to provide enhanced passive skin permeation of various active drugs for the treatment of many conditions, including hypogonadism, female sexual dysfunction, postmenopausal symptoms, overactive bladder and anxiety. The technology consists of a combination of solvent systems and permeation enhancers enabling systemic drug delivery, and is covered by many patents. Pharmaceutical development of formulations based on the technology allowed optimisation of physicochemical parameters (rheological profile, pH) as well as skin permeation properties (type and concentration of permeation enhancers, thermodynamic activity of the drug). This gel technology has demonstrated to be efficient for many drugs, as shown in the preclinical and clinical pharmacokinetic studies presented in this technology evaluation. |
| Databáze: | OpenAIRE |
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