Anti-inflammatory Activity of n-Propyl Gallate Through Down-regulation of NF-κB and JNK Pathways
| Autor: | Kyunghoon Kim, Byung-Chul Kim, Hyun-Joo Jung, Eun-Hee Park, Chang-Jin Lim, Kisup Ahn, Young-Myeong Kim, Woo-Kwang Jeon, Su-Jung Kim |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Lipopolysaccharide MAP Kinase Signaling System Immunology Down-Regulation Nitric Oxide Synthase Type II Nitric Oxide Cell Line Nitric oxide Rats Sprague-Dawley Mice chemistry.chemical_compound Animals Immunology and Allergy Macrophage Propyl Gallate Propyl gallate Inflammation chemistry.chemical_classification Mice Inbred ICR Reactive oxygen species biology Kinase Macrophages Anti-Inflammatory Agents Non-Steroidal JNK Mitogen-Activated Protein Kinases NF-kappa B Gallate Molecular biology Matrix Metalloproteinases Rats Nitric oxide synthase chemistry Biochemistry Cyclooxygenase 2 biology.protein Reactive Oxygen Species Signal Transduction |
| Zdroj: | Inflammation. 34:352-361 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/s10753-010-9241-0 |
| Popis: | The present study aimed to assess anti-inflammatory activity and underlying mechanism of n-propyl gallate, the n-propyl ester of gallic acid. n-Propyl gallate was shown to contain anti-inflammatory activity using two experimental animal models, acetic acid-induced permeability model in mice, and air pouch model in rats. It suppressed production of nitric oxide and induction of inducible nitric oxide synthase and cyclooxygenase-2 in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. It was able to diminish reactive oxygen species level elevated in the LPS-stimulated RAW264.7 macrophage cells. It also suppressed gelatinolytic activity of matrix metalloproteinase-9 enhanced in the LPS-stimulated RAW264.7 macrophage cells. It inhibited inhibitory κB-α degradation and enhanced NF-κB promoter activity in the stimulated macrophage cells. It was able to suppress phosphorylation of c-Jun NH(2)-terminal kinase 1/2 (JNK1/2) and activation of c-Jun promoter activity in the stimulated macrophage cells. In brief, n-propyl gallate possesses anti-inflammatory activity via down-regulation of NF-κB and JNK pathways. |
| Databáze: | OpenAIRE |
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