Application of Arterial Spin Labelling in Detecting Retinal Ischemia
| Autor: | David Squirrell, Ehsan Vaghefi, Wilson Pan, Kevin Kauv |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Ischemia
Spin labelling Case Report Arterial spin labelling 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology medicine Chorioretinal ischemia Fixation (histology) medicine.diagnostic_test business.industry Retinal ischemia medicine.disease Ophthalmology medicine.anatomical_structure lcsh:RE1-994 Angiography 030221 ophthalmology & optometry Breathing Chorioretinal blood flow Choroid business Nuclear medicine Perfusion |
| Zdroj: | Case Reports in Ophthalmology, Vol 8, Iss 3, Pp 545-557 (2017) Case Reports in Ophthalmology |
| ISSN: | 1663-2699 |
| Popis: | Purpose: Here, we have tried to quantify the chorioretinal blood perfusion in patients who are clinically identified to be suffering from retinal ischemia using arterial spin labelling (ASL) MRI. Method: Four participants, diagnosed with retinal ischemia based on their structural OCT and angiography test, were then scanned using anatomical MRI as well as ASL. We optimized MR parameters to maximize resolution and target fixation, blinking, and breathing ques to minimize motion artifacts. Results: Participants had a maximum of ∼50 mL/100 mL/min of blood perfusion, which is below the normal values of ∼200 mL/100 mL/min. It also appeared that thinning of the choroid contributes more to the measured decreased chorioretinal perfusion, compared to slowed arterial filling time. Conclusion: Decreased chorioretinal perfusion is a multifactorial event and has been implicated in several posterior eye pathologies. Based on our current results, it seems that ischemia of the eye could be due to anatomy (tissue volume) and/or functionality (arterial flow). |
| Databáze: | OpenAIRE |
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